Area of research
Molecular Biology · Pulmonary and Respiratory Medicine
Research interest
Research interests include DNA Repair Mechanisms, Lung Cancer Treatments and Mutations, BRCA gene mutations in cancer, and CRISPR and Genetic Engineering.
Defective BRCA1-mediated DNA end resection drives tandem duplication formation and
<i>FANCM</i>
synthetic lethality
Extracellular vesicles from antler blastema progenitor cells reverse bone loss and mitigate aging-related phenotypes in mice and macaques
Targeting c-MET Alterations in Cancer: A Review of Genetic Drivers and Therapeutic Implications.
Ergosterol Regulates Visceral Hypersensitivity and Intestinal Motility in Irritable Bowel Syndrome Through Microbiota–Metabolites–AhR Signaling Axis
Clinical features and outcomes of unresectable locally advanced lung adenocarcinoma with uncommon EGFR mutations: a retrospective multi-center Chinese study
Cosiporfin sodium (DVDMS)-mediated photodynamic therapy (PDT) versus treatment of physician’s choice (TPC) in patients (pts) with advanced esophageal cancer (aEC): A phase III, randomized, open-label, multicenter trial.
EP300 deficiency leads to chronic replication stress mediated by defective replication fork protection.
<i>Lactiplantibacillus plantarum</i> Regulates Intestinal Physiology and Enteric Neurons in IBS through Microbial Tryptophan Metabolites
First-line zorifertinib for EGFR-mutant non-small cell lung cancer with central nervous system metastases: The phase 3 EVEREST trial
DSS1 restrains BRCA2's engagement with dsDNA for homologous recombination, replication fork protection, and R-loop homeostasis.
Disrupted BRCA1-PALB2 interaction induces tumor immunosuppression and T-lymphocyte infiltration in HCC through cGAS-STING pathway.
Human microglia maturation is underpinned by specific gene regulatory networks
Phase I/II combination study of tifcemalimab with toripalimab in patients with refractory extensive stage small cell lung cancer (ES-SCLC).
Disrupted BRCA1‐PALB2 interaction induces tumor immunosuppression and T‐lymphocyte infiltration in HCC through cGAS‐STING pathway
BRCA1-Dependent and Independent Recruitment of PALB2-BRCA2-RAD51 in the DNA Damage Response and Cancer.
Tumor suppressor PALB2 maintains redox and mitochondrial homeostasis in the brain and cooperates with ATG7/autophagy to suppress neurodegeneration.
Loss of the BRCA1-PALB2 interaction accelerates p53-associated tumor development in mice
Functional cooperation between ATG7/autophagy and the PALB2 tumor suppressor in mitochondrial regulation, redox homeostasis, and neuronal health.
A protein interaction landscape of breast cancer
A protein interaction landscape of breast cancer.
BRCA2 associates with MCM10 to suppress PRIMPOL-mediated repriming and single-stranded gap formation after DNA damage.
Impact of XPO1 mutations on survival outcomes in metastatic non-small cell lung cancer (NSCLC)
Genetic interactions among Brca1, Brca2, Palb2, and Trp53 in mammary tumor development.
OA02.06 PSM Analysis Results from REFRACT: A Multi-Center Cohort Study Investigating the Treatment Patterns in EGFR-Mutant Unresectable LA- NSCLC
PALB2 maintains redox and mitochondrial homeostasis in the brain and cooperates with ATG7 to suppress p53 dependent neurodegeneration
Performance and Its Limits in Rigid Body Protein-Protein Docking
The Warburg effect promoted the activation of the NLRP3 inflammasome induced by Ni-refining fumes in BEAS-2B cells
Kinase Atlas: Druggability Analysis of Potential Allosteric Sites in Kinases
Homologous recombination DNA repair defects in PALB2-associated breast cancers