Area of research
Structural Biology · Cellular and Molecular Neuroscience
Research interest
Research interests include Advanced Electron Microscopy Techniques and Applications, Photoreceptor and optogenetics research, Electron and X-Ray Spectroscopy Techniques, and Neuroscience and Neuropharmacology Research.
Mutations in VCP cause Adams-Oliver syndrome with or without pulmonary hypertension.
Therapeutic Antibodies for Infectious Diseases: Recent Past, Present, and Future.
Community recommendations on cryoEM data archiving and validation
Community recommendations on cryoEM data archiving and validation.
Altered receptor binding, antibody evasion and retention of T cell recognition by the SARS-CoV-2 XBB.1.5 spike protein.
AAA ATPase protein-protein interactions as therapeutic targets in cancer.
Structural biology in the age of AI.
Autoinhibition of a clamp-loader ATPase revealed by deep mutagenesis and cryo-EM
Cryo-EM structure determination of small therapeutic protein targets at 3 Å-resolution using a rigid imaging scaffold
Cryo-EM structure determination of small therapeutic protein targets at 3 Å-resolution using a rigid imaging scaffold.
Allosteric modulation of ryanodine receptor RyR1 by nucleotide derivatives.
Structural analysis of receptor engagement and antigenic drift within the BA.2 spike protein.
Learning from Gobind Khorana: "The difficult we do today, the impossible tomorrow".
SARS-CoV-2 Omicron variant: Antibody evasion and cryo-EM structure of spike protein–ACE2 complex
SARS-CoV-2 Omicron variant: Antibody evasion and cryo-EM structure of spike protein-ACE2 complex.
Structural and biochemical rationale for enhanced spike protein fitness in delta and kappa SARS-CoV-2 variants.
A paradigm shift in structural biology.
SARS-CoV-2 variants of concern: spike protein mutational analysis and epitope for broad neutralization.
Three-Dimensional Visualization of Viral Structure, Entry, and Replication Underlying the Spread of SARS-CoV-2.
Comparison of side-chain dispersion in protein structures determined by cryo-EM and X-ray crystallography.
Introduction: Cryo-EM in Biology and Materials Research.
Cryo-electron microscopy structures of the N501Y SARS-CoV-2 spike protein in complex with ACE2 and 2 potent neutralizing antibodies.
Structural analysis of receptor binding domain mutations in SARS-CoV-2 variants of concern that modulate ACE2 and antibody binding
A molecular mechanism for the generation of ligand-dependent differential outputs by the epidermal growth factor receptor.
Malaria parasites use a soluble RhopH complex for erythrocyte invasion and an integral form for nutrient uptake.
New insights into Raf regulation from structural analyses
New insights into Raf regulation from structural analyses.
Structural Analysis of Receptor Binding Domain Mutations in SARS-CoV-2 Variants of Concern that Modulate ACE2 and Antibody Binding
Glycan reactive anti-HIV-1 antibodies bind the SARS-CoV-2 spike protein but do not block viral entry