Area of research
Infectious Diseases · Epidemiology
Research interest
Research interests include Tuberculosis, Mycobacterium tuberculosis, Chemistry, Microbiology, In vivo, and Stereochemistry.
Discovery of New Cyclic Lipodepsipeptide Orfamide N via Partnership with Middle School Students from the Boys and Girls Club
Identification of the inhibitory mechanism of ecumicin and rufomycin 4-7 on the proteolytic activity of Mycobacterium tuberculosis ClpC1/ClpP1/ClpP2 complex
Targeted Antitubercular Peptide Nanocarriers Prepared by Flash NanoPrecipitation with Hydrophobic Ion Pairing
Rufomycins or Ilamycins: Naming Clarifications and Definitive Structural Assignments
<i>In Vitro</i>Profiling of Antitubercular Compounds by Rapid, Efficient, and Nondestructive Assays Using Autoluminescent Mycobacterium tuberculosis
New tuberculosis drug targets, their inhibitors, and potential therapeutic impact
Antimycobacterial Rufomycin Analogues from <i>Streptomyces atratus</i> Strain MJM3502
Structure of the N-terminal domain of ClpC1 in complex with the antituberculosis natural product ecumicin reveals unique binding interactions
Rufomycin Targets ClpC1 Proteolysis in Mycobacterium tuberculosis and M. abscessus
Strategies in anti-Mycobacterium tuberculosis drug discovery based on phenotypic screening
High-Resolution Structure of ClpC1-Rufomycin and Ligand Binding Studies Provide a Framework to Design and Optimize Anti-Tuberculosis Leads
Suadimins A–C, Unprecedented Dimeric Quinoline Alkaloids with Antimycobacterial Activity from <i>Melodinus suaveolens</i>
Antimicrobial Lavandulylated Flavonoids from a Sponge-Derived Streptomyces sp. G248 in East Vietnam Sea
Residual Complexity Does Impact Organic Chemistry and Drug Discovery: The Case of Rufomyazine and Rufomycin
QSAR-driven design, synthesis and discovery of potent chalcone derivatives with antitubercular activity
Design, Synthesis, and Characterization of N-Oxide-Containing Heterocycles with in Vivo Sterilizing Antitubercular Activity
Mutation in <i>clpC1</i> encoding an ATP-dependent ATPase involved in protein degradation is associated with pyrazinamide resistance in <i>Mycobacterium tuberculosis</i>
Biophysical Screening of a Focused Library for the Discovery of CYP121 Inhibitors as Novel Antimycobacterials
Arrival of Imidazo[2,1-<i>b</i>]thiazole-5-carboxamides: Potent Anti-tuberculosis Agents That Target QcrB
Design, Syntheses, and Anti-TB Activity of 1,3-Benzothiazinone Azide and Click Chemistry Products Inspired by BTZ043
Bioautography with TLC-MS/NMR for Rapid Discovery of Anti-tuberculosis Lead Compounds from Natural Sources
Imidazo[1,2- <i>a</i> ]Pyridine-3-Carboxamides Are Active Antimicrobial Agents against Mycobacterium avium Infection <i>In Vivo</i>
Design, syntheses, and anti-tuberculosis activities of conjugates of piperazino-1,3-benzothiazin-4-ones (pBTZs) with 2,7-dimethylimidazo [1,2-a]pyridine-3-carboxylic acids and 7-phenylacetyl cephalosporins
Microplate Alamar Blue Assay (MABA) and Low Oxygen Recovery Assay (LORA) for Mycobacterium tuberculosis
Diaza-anthracene Antibiotics from a Freshwater-Derived Actinomycete with Selective Antibacterial Activity toward <i>Mycobacterium tuberculosis</i>
Trichormamides C and D, antiproliferative cyclic lipopeptides from the cultured freshwater cyanobacterium cf. Oscillatoria sp. UIC 10045
Syntheses and evaluation of substituted aromatic hydroxamates and hydroxamic acids that target Mycobacterium tuberculosis
The Cyclic Peptide Ecumicin Targeting ClpC1 Is Active against Mycobacterium tuberculosis In Vivo
<i>In Vitro</i> and <i>In Vivo</i> Activities of the Nitroimidazole TBA-354 against Mycobacterium tuberculosis
Discovery and Characterization of the Tuberculosis Drug Lead Ecumicin