Area of research
Molecular Biology · Cancer Research
Research interest
Research interests include Epigenetics and DNA Methylation, RNA modifications and cancer, Cancer, Hypoxia, and Metabolism, and Cancer Genomics and Diagnostics.
Arid1a Deficiency Drives Aristolochic Acid-Induced Liver Tumorigenesis through Ctnnb1 Mutation and Defective Nucleotide Excision Repair.
Lysosome-localized IRTKS condensates promote mTORC1 activity leading to MASLD and HCC.
Single-cell and spatial transcriptomics uncover neoadjuvant chemotherapy-resistant malignant cells with inhibitory signalling on B cells in gastric cancer.
Characterization of the extrinsic and intrinsic signatures and therapeutic vulnerability of small cell lung cancers
De Novo Detection of Clonal Structure and Evolution in Single-Cell and Spatial Transcriptomes.
Liquid Guardians: Biomolecular Condensates Shield Heterochromatin Against Cellular Senescence.
Deciphering context-specific gene programs from single-cell and spatial transcriptomics data with DeCEP.
Dendritic-cell-targeting virus-like particles as potent mRNA vaccine carriers
Heterochromatin formation and remodeling by IRTKS condensates counteract cellular senescence.
BAIAP2L1 and BAIAP2L2 differently regulate hair cell stereocilia morphology.
MA14.05 Tumor Tissue and Plasma EGFR Exon 20 Insertion Mutation Status in NSCLC Patients Treated with Sunvozertinib
562P First-line (1L) osimertinib (osi) ± platinum-pemetrexed in patients (pts) with EGFRm advanced NSCLC: FLAURA2 China cohort
BRD4 inhibition induces synthetic lethality in ARID2-deficient hepatocellular carcinoma by increasing DNA damage.
2MO Final OS results and subgroup analysis of savolitinib in patients with MET exon 14 skipping mutations (METex14+) NSCLC
DLK1-directed chimeric antigen receptor T-cell therapy for hepatocellular carcinoma.
Accurate tumor clonal structures require single‐cell analysis
A novel 8-shape trajectory weaving welding control algorithm with auto-adjust welding torch attitude
Exposure to aristolochic acid I is associated with poor prognosis of liver cancer patients.
Clonal evolution in liver cancer at single-cell and single-variant resolution
ARID1A deficiency weakens BRG1-RAD21 interaction that jeopardizes chromatin compactness and drives liver cancer cell metastasis.
LZP is required for hepatic triacylglycerol transportation through maintaining apolipoprotein B stability.
MA13.08 CHOICE-01: A Phase 3 Study of Toripalimab Versus Placebo in Combination With First-Line Chemotherapy for Advanced NSCLC
Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection
SARS-CoV-2 Orf9b suppresses type I interferon responses by targeting TOM70
Investigating higher-order interactions in single-cell data with scHOT
Mutational and transcriptomic landscapes of a rare human prostate basal cell carcinoma
scMerge leverages factor analysis, stable expression, and pseudoreplication to merge multiple single-cell RNA-seq datasets
Investigating higher order interactions in single cell data with scHOT
SCFFBW7-mediated degradation of Brg1 suppresses gastric cancer metastasis
VEGF amplifies transcription through ETS1 acetylation to enable angiogenesis