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Yan Chen

Macau University of Science and Technology · MO
Area of research
Molecular Biology · Physiology
Research interest
Research interests include Phosphodiesterase function and regulation, Nitric Oxide and Endothelin Effects, MicroRNA in disease regulation, and Renin-Angiotensin System Studies.
h-index
72
citations
17,791
works
592
NIH funding
primary concept
email

Recent publications

Fast growth and high-titer bioproduction from renewable formate via metal-dependent formate dehydrogenase in Escherichia coli
Nature Communications 2025cited by 22position: middledoi
Ultrasound‐Responsive Piezoelectric Membrane Promotes Osteoporotic Bone Regeneration via the “Two‐Way Regulation” Bone Homeostasis Strategy
Advanced Science 2025cited by 16position: middledoi
SARM1 senses dsDNA to promote NAD+ degradation and cell death
Cell 2025cited by 4position: middledoi
Association between dietary inflammatory index and endometriosis in the US population: A cross-sectional study
Experimental Gerontology 2025cited by 1position: firstdoi
Toripalimab combined with FLOT chemotherapy as conversion therapy for gastric cancer with peritoneal metastasis: a single-arm, open-label, phase II trial
BMC Cancer 2025cited by 0position: middledoi
Functional plasticity of HCO3– uptake and CO2 fixation in Cupriavidus necator H16
Bioresource Technology 2024cited by 15position: middledoi
WITHDRAWN: Truncated NLRC5 isoforms in human placenta: expression, regulation by miR-218-5p, and function in trophoblasts
bioRxiv (Cold Spring Harbor Laboratory) 2024cited by 0position: middledoi
Small molecule agonist of mitochondrial fusion repairs mitochondrial dysfunction
Nature Chemical Biology 2023cited by 74position: middledoi
Homoharringtonine-Based Induction Regimen Improved the Remission Rate and Survival Rate in Chinese Childhood AML: A Report From the CCLG-AML 2015 Protocol Study
Journal of Clinical Oncology 2023cited by 31position: middledoi
Additional file 1 of Tumor microenvironment remodeling after neoadjuvant immunotherapy in non-small cell lung cancer revealed by single-cell RNA sequencing
Figshare 2023cited by 0position: middledoi
miR-218-5p Induces Interleukin-1β and Endovascular Trophoblast Differentiation by Targeting the Transforming Growth Factor β-SMAD2 Pathway
Frontiers in Endocrinology 2022cited by 12position: middledoi
Circ_0006873 Sponges miR-142-5p to Inhibit Osteoblastic Differentiation of hBMSCs via Regulating PTEN/Akt Signaling Pathway.
PubMed 2022cited by 11position: middle
Comparative efficacy of Chinese herbal injections for septic shock: A protocol for systematic review and network meta-analysis.
PubMed 2022cited by 0position: middledoi
Beta-amyloid deposition around hepatic bile ducts is a novel pathobiological and diagnostic feature of biliary atresia
Journal of Hepatology 2020cited by 63position: middledoi
Identification of diterpenoid compounds that interfere with Fli-1 DNA binding to suppress leukemogenesis
Cell Death and Disease 2019cited by 54position: middledoi
Acetophenone derivatives from the root bark of Cynanchum wilfordii as potential neuroprotective agents
Phytochemistry Letters 2018cited by 7position: middledoi
Glutaredoxin 1 mediates the protective effect of steady laminar flow on endothelial cells against oxidative stress-induced apoptosis via inhibiting Bim
Scientific Reports 2017cited by 25position: middledoi
Poster
Diabetes/Metabolism Research and Reviews 2017cited by 1position: middledoi
Protein kinase C controls lysosome biogenesis independently of mTORC1
Nature Cell Biology 2016cited by 357position: middledoi
EGF-stimulated activation of Rab35 regulates RUSC2–GIT2 complex formation to stabilize GIT2 during directional lung cancer cell migration
Cancer Letters 2016cited by 30position: middledoi
Absorption and Metabolism Characteristics of Triptolide as Determined by a Sensitive and Reliable LC-MS/MS Method
Molecules 2015cited by 32position: middledoi
A small natural molecule promotes mitochondrial fusion through inhibition of the deubiquitinase USP30
Cell Research 2014cited by 210position: middledoi
Serum miR-210 and miR-30a expressions tend to revert to fetal levels in Chinese adult patients with chronic heart failure
Cardiovascular Pathology 2013cited by 59position: middledoi
Smooth Muscle Cell Plasticity
Circulation Research 2012cited by 161position: middledoi
CYLD negatively regulates transforming growth factor-β-signalling via deubiquitinating Akt
Nature Communications 2012cited by 148position: middledoi
Phosphoinositide 3-Kinase γ Protects Against Catecholamine-Induced Ventricular Arrhythmia Through Protein Kinase A–Mediated Regulation of Distinct Phosphodiesterases
Circulation 2012cited by 87position: middledoi
p90RSK Targets the ERK5-CHIP Ubiquitin E3 Ligase Activity in Diabetic Hearts and Promotes Cardiac Apoptosis and Dysfunction
Circulation Research 2012cited by 56position: middledoi

Grants

PFI-TT: Development and Integration of Tire Blowout Modeling and Control for Safe, Automated Driving
NSF2415002$550,0002024–2027PIRePORTER
Collaborative Research: CNS Core: Small: Accelerating Serverless Cloud Network Performance
NSF2229454$300,0002023–2026PIRePORTER
RINGS: Accelerating the NextG Protocols Definition to Code Generation with an Automatic and Secure Verification-Compilation Tool-Chain
NSF2148177$899,9982022–2026PIRePORTER
EAGER: DCL: SaTC: Enabling Interdisciplinary Collaboration: Adapting Economic Games to Personalize Privacy and Security Nudges
NSF2209507$315,9972022–2025PIRePORTER
GOALI: Modeling, Evaluation, and Control of Tire Blowout for Automated and Partially Automated Vehicles
NSF2043286$310,0002021–2024PIRePORTER
I-Corps: AdsProphet: Full-screen Delay-aware Mobile Ads Display
NSF1558209$50,0002015–2016PIRePORTER
TWC: TTP Option: Medium: Collaborative: Identifying and Mitigating Trust Violations in the Smartphone Ecosystem
NSF1408790$533,9202014–2018PIRePORTER
NeTS: Small: WaveCube: A Scalable, Fault-Tolerant, High-Performance Optical Data Center Architecture
NSF1219116$400,0002012–2015PIRePORTER
Social Identity in Online Microfinance and Public Goods Provision
NSF1111019$500,0002011–2015PIRePORTER
Collaborative Research: School Choice and College Admissions: Theory and Experiments
NSF0962492$233,4672010–2014PIRePORTER
CT-ISG: High-Speed Network Defense with Massive and Diverse Vulnerability Signatures
NSF0831508$400,0002008–2012PIRePORTER
REU Site: Incentive-Centered Design for Cyberinfrastructure
NSF0755147$286,7432008–2012PIRePORTER
IGERT: Incentive-Centered Design for Information and Communication Systems
NSF0654014$3,000,0002007–2014PIRePORTER
Collaborative Research: Social Identity, Mechanism Design and Equilibrium Selection
NSF0720943$232,3632007–2011PIRePORTER
CT-ISG: Router-Based Signature Generation for Zero-Day Polymorphic Worms
NSF0627751$200,0002006–2009PIRePORTER
EITM: Matching: An Experimental Study
NSF0339587$227,8002004–2008PIRePORTER
An Experimental Study of Strategic Complementarity, Asynchronicity and Mechanism Design
NSF0079001$200,7302000–2005PIRePORTER
Mechanism Design for Indivisible Goods Allocation
NSF9904214$65,7691999–2001PIRePORTER
POWRE: Supermodularity of Nash-Efficient Public Goods Mechanism: Theory and Experiments
NSF9805586$50,0001998–2000PIRePORTER

Frequent collaborators

Xiao‐Jiang Hao · Guangzhou University of Chinese Medicine3 papers (2014–2019)Chang-Hoon Woo · Yeungnam University2 papers (2012–2012)Jelena Brkić · York University2 papers (2022–2024)Sara Tejedor‐Sanz · Lawrence Berkeley National Laboratory2 papers (2024–2025)Christopher J. Petzold · New York University2 papers (2024–2025)Chun Peng · Huazhong Agricultural University2 papers (2022–2024)Kyung‐Sun Heo · Chungnam National University2 papers (2012–2012)Jin Zhang · Fujian Medical University1 papers (2012–2012)Jinhua Liu · Nanchang University1 papers (2014–2014)Zhiqing Liu · Nanjing Agricultural University1 papers (2025–2025)Lei Xia · Nanjing Agricultural University1 papers (2019–2019)Lixiang Lin · Guangdong University of Technology1 papers (2022–2022)Bin Wang · Xinjiang Academy of Agricultural Sciences1 papers (2020–2020)Yi Huang · Tibet University1 papers (2025–2025)Shan Hu · Guangzhou University of Chinese Medicine1 papers (2025–2025)Haobo Zhang · Guangzhou University of Chinese Medicine1 papers (2022–2022)Tianlong Wang · Tongji University1 papers (2025–2025)Xiaochi Ma · Tianjin University of Traditional Chinese Medicine1 papers (2025–2025)Jie Geng · Shanxi Medical University1 papers (2013–2013)Wenjun Xiong · Guangzhou University of Chinese Medicine1 papers (2025–2025)