Area of research
Molecular Biology · Organic Chemistry
Research interest
Research focused on Matrine and Chalcone, with related work in Cancer research, Sophora flavescens, Pharmacology. Notable publications include 'The entry of nanoparticles into solid tumours', 'Chemical properties and antioxidant activity of a water-soluble polysaccharide from Dendrobium officinale', and 'Research advances on anticancer activities of matrine and its derivatives: An updated overview'.
Interpretable machine learning models for predicting the antitumor effects of metal and metal oxide nanomaterials
Advances in liposomes loaded with photoresponse materials for cancer therapy
Novel chiral matrine derivatives as potential antitumor agents: Design, synthesis and biological evaluation
Self-Assembled Matrine-PROTAC Encapsulating Zinc(II) Phthalocyanine with GSH-Depletion-Enhanced ROS Generation for Cancer Therapy
QSAR prediction, synthesis, anticancer evaluation, and mechanistic investigations of novel sophoridine derivatives as topoisomerase I inhibitors
Machine Learning and Quantum Calculation for Predicting Yield in Cu-Catalyzed P–H Reactions
Novel anthraquinone photosensitizers: Synthesis, photoactivity, and 3D-QSAR studies
A Review of The Application of Spectroscopy to Flavonoids from Medicine and Food Homology Materials
Induction of Apoptosis by Matrine Derivative ZS17 in Human Hepatocellular Carcinoma BEL-7402 and HepG2 Cells through ROS-JNK-P53 Signalling Pathway Activation
Novel matrinic acid derivatives bearing 2‐anilinothiazole structure for non‐small cell lung cancer treatment with improved Hsp90 targeting effect
Matrine family derivatives: Synthesis, reactions procedures, mechanism, and application in medicinal, agricultural, and materials chemistry
Organocatalytic 1,6-hydrophosphination of <i>para</i>-quinone methides: enantioselective access to chiral 3-phosphoxindoles bearing phosphorus-substituted quaternary carbon stereocenters
Hydroquinine-catalyzed asymmetric 1,4-hydrophosphination of <i>in situ</i> generated aza-<i>o</i>-quinone methides with <i>H</i>-phosphine oxides
Purification, structural elucidation and immunostimulatory effect of a new protein-polysaccharide conjugate produced by <i>Nervilia fordii</i>
The entry of nanoparticles into solid tumours
New modification strategy of matrine as Hsp90 inhibitors based on its specific L conformation for cancer treatment
Chlorin e6-loaded sonosensitive magnetic nanoliposomes conjugated with the magnetic field for enhancing anti-tumor effect of sonodynamic therapy
Promising anti-inflammatory effects of chalcones via inhibition of cyclooxygenase, prostaglandin E2, inducible NO synthase and nuclear factor κb activities
An Oncolytic Adenovirus Targeting Transforming Growth Factor β Inhibits Protumorigenic Signals and Produces Immune Activation: A Novel Approach to Enhance Anti-PD-1 and Anti-CTLA-4 Therapy
Design, synthesis and evaluation of novel (S)-tryptamine derivatives containing an allyl group and an aryl sulfonamide unit as anticancer agents
Design, synthesis, and biological evaluation of matrine derivatives possessing piperazine moiety as antitumor agents
Design, synthesis and biological evaluation of 1,4-dihydroxyanthraquinone derivatives as anticancer agents
Research advances on anticancer activities of matrine and its derivatives: An updated overview
Design, synthesis, biological evaluation and structure-activity relationship of sophoridine derivatives bearing pyrrole or indole scaffold as potential antitumor agents
Design, synthesis and biological evaluation of matrine derivatives as potential anticancer agents
Design, synthesis and evaluation of novel sophoridinic imine derivatives containing conjugated planar structure as potent anticancer agents
Novel indolo-sophoridinic scaffold as Topo I inhibitors: Design, synthesis and biological evaluation as anticancer agents
Design, synthesis, and biological evaluation of thiomatrine derivatives as potential anticancer agents
Metal- and Base-Free Electrophilic Addition of 3-Diazooxindoles with <i>H</i> -phosphine Oxides for N–P Bond Formation
Corrigendum to “Design, synthesis, biological evaluation, and molecular docking of chalcone derivatives as anti-inflammatory agents” [Bioorg. Med. Chem. Lett. 27 (3) (2017) 602–606]