Area of research
Complementary and alternative medicine · Cognitive Neuroscience
Research interest
Research topics from publications: A novel antibody targeting sequence 31–35 in amyloid β protein attenuates Alzheimer's disease‐related neuronal damage. Representative work: ABSTRACT Amyloid β protein (Aβ) plays a critical role in pathogenesis of Alzheimer's disease (AD). Our previous studies indicated that the sequence 31–35 in Aβ molecule is an effective active center responsible for Aβ neurotoxicity in vivo and in vitro . In the present study, we prepared a novel antibody specifically targeting the sequence 31–35 of amyloid β protein, and investigated the neuroprotection of the anti‐Aβ 31–35 antibody against Aβ 1–42 ‐induced impairments in neuronal viability, spatial memory, and hippocampal synaptic plasticity in rats. The results showed that the anti‐Aβ 31–35 antibody almost equally bound to both Aβ 31–35 and Aβ 1–42 , and pretreatment with the antibody dose