Area of research
Hematology · Immunology
Research interest
Research focused on Platelet and Inflammation, with related work in Protein disulfide-isomerase, Cell biology, Thrombosis. Notable publications include 'YAP Controls Endothelial Activation and Vascular Inflammation Through TRAF6', 'Scalable Generation of Universal Platelets from Human Induced Pluripotent Stem Cells', and 'A directional switch of integrin signalling and a new anti-thrombotic strategy'.
A Critical Role for ERO1α in Arterial Thrombosis and Ischemic Stroke
Shear and Integrin Outside-In Signaling Activate NADPH-Oxidase 2 to Promote Platelet Activation
Platelet Protein Disulfide Isomerase Promotes Glycoprotein Ibα–Mediated Platelet-Neutrophil Interactions Under Thromboinflammatory Conditions
YAP Controls Endothelial Activation and Vascular Inflammation Through TRAF6
Myeloperoxidase Negatively Regulates Neutrophil–Endothelial Cell Interactions by Impairing αMβ2 Integrin Function in Sterile Inflammation
Differential Roles of the NADPH-Oxidase 1 and 2 in Platelet Activation and Thrombosis
Signaling-mediated cooperativity between glycoprotein Ib-IX and protease-activated receptors in thrombin-induced platelet activation
ARQ 092, an orally-available, selective AKT inhibitor, attenuates neutrophil-platelet interactions in sickle cell disease
Platelet–neutrophil interactions under thromboinflammatory conditions
NOX2 is critical for heterotypic neutrophil-platelet interactions during vascular inflammation
Hydroxyurea with AKT2 inhibition decreases vaso-occlusive events in sickle cell disease mice
Scalable Generation of Universal Platelets from Human Induced Pluripotent Stem Cells
Neutrophil AKT2 regulates heterotypic cell-cell interactions during vascular inflammation
Agonist-induced platelet procoagulant activity requires shear and a Rac1-dependent signaling mechanism
A directional switch of integrin signalling and a new anti-thrombotic strategy
Platelet protein disulfide isomerase is required for thrombus formation but not for hemostasis in mice
Extracellular protein disulfide isomerase regulates ligand-binding activity of αMβ2 integrin and neutrophil recruitment during vascular inflammation
G protein–dependent basal and evoked endothelial cell vWF secretion