Area of research
Molecular Biology · Genetics
Research interest
Research interests include Epigenetics and DNA Methylation, Glioma Diagnosis and Treatment, Cancer-related gene regulation, and Histone Deacetylase Inhibitors Research.
Synthesis, Structure-Activity Relationships, and Antitumor Activities of Quinoxiline-Containing Inhibitors of the Protein-Protein Interactions between Transcription Coactivator AF9/ENL and DOT1L/AF4.
Targeting the S1' Pocket of SARS-CoV‑2 Papain-Like Protease Yields Highly Potent Inhibitors.
Perspective for Drug Discovery Targeting SARS Coronavirus Methyltransferases: Function, Structure and Inhibition.
Design, Synthesis, X-ray Crystallography, and Biological Activities of Covalent, Non-Peptidic Inhibitors of SARS-CoV-2 Main Protease.
Quinazolinone Compounds Have Potent Antiviral Activity against Zika and Dengue Virus.
In vitro and in vivo characterization of erythrosin B and derivatives against Zika virus
Synthesis, Structure-Activity Relationships, and Antiviral Activity of Allosteric Inhibitors of Flavivirus NS2B-NS3 Protease.
Acetylation of histone H3K27 signals the transcriptional elongation for estrogen receptor alpha
Discovery, Structure-Activity Relationship, and Biological Activity of Histone-Competitive Inhibitors of Histone Acetyltransferases P300/CBP.
Discovery, X-ray Crystallography and Antiviral Activity of Allosteric Inhibitors of Flavivirus NS2B-NS3 Protease
Discovery, X-ray Crystallography and Antiviral Activity of Allosteric Inhibitors of Flavivirus NS2B-NS3 Protease.
Targeting histone methylation for cancer therapy: enzymes, inhibitors, biological activity and perspectives
DOT1L as a therapeutic target for the treatment of DNMT3A-mutant acute myeloid leukemia
Small-molecule inhibition of STAT3 in radioresistant head and neck squamous cell carcinoma
An epigenomic approach to therapy for tamoxifen-resistant breast cancer
GATA2 facilitates steroid receptor coactivator recruitment to the androgen receptor complex
Critical role of retinoid/rexinoid signaling in mediating transformation and therapeutic response of NUP98-RARG leukemia