Area of research
Molecular Biology
Research interest
Research focused on CRISPR and Trans-activating crRNA, with related work in RNA, Protein subunit, Gene silencing. Notable publications include 'Inhibition of cGAS DNA Sensing by a Herpesvirus Virion Protein', 'Bipartite recognition of target RNAs activates DNA cleavage by the Type III-B CRISPR–Cas system', and 'High-yield genome engineering in primary cells using a hybrid ssDNA repair template and small-molecule cocktails'.
A phage-encoded anti-CRISPR protein co-opts host enolase to prevent type III CRISPR immunity
The twist-and-squeeze activation of CARF-fused adenosine deaminase by cyclic oligoadenylates
Recent research advances on polysaccharide-, peptide-, and protein-based hemostatic materials: A review
Molecular basis for cA6 synthesis by a type III-A CRISPR–Cas enzyme and its conversion to cA4 production
Unveil the Molecular Interplay between Aminoglycosides and Pseudouridine in IRES Translation
A CRISPR-associated Rossman-fold Ring Nuclease and Adenosine Deaminase Fusion Allosterically Converts ATP to ITP
Coupled catalytic states and the role of metal coordination in Cas9
Regulation of translation by ribosomal RNA pseudouridylation
High-yield genome engineering in primary cells using a hybrid ssDNA repair template and small-molecule cocktails
CryoEM structures of pseudouridine-free ribosome suggest impacts of chemical modifications on ribosome conformations
Structural principles of CRISPR-Cas enzymes used in nucleic acid detection
Molecular mechanism of active Cas7-11 in processing CRISPR RNA and interfering target RNA
Structural and biochemical characterization of in vivo assembled Lactococcus lactis CRISPR-Csm complex
Artificial intelligence-assisted cryoEM structure of Bfr2-Lcp5 complex observed in the yeast small subunit processome
Author response: Molecular mechanism of active Cas7-11 in processing CRISPR RNA and interfering target RNA
Mechanistic studies and application of a type-IIIA CRISPR-Cas system
“X” marks the spot: Mining the gold in CasX for gene editing
Virus detection via programmable Type III-A CRISPR-Cas systems
Catalytically Enhanced Cas9 Through Directed Protein Evolution
Structure and Function of an in vivo Assembled Type III-A CRISPR-Cas Complex Reveal Critical Roles of Dynamics in Activity Control
Pseudouridine-free Ribosome Exhibits Distinct Inter-subunit Movements
ALKBH1 promotes lung cancer by regulating m6A RNA demethylation
The molecular basis for recognition of 5′-NNNCC-3′ PAM and its methylation state by Acidothermus cellulolyticus Cas9
Catalytically Enhanced Cas9 through Directed Protein Evolution
A Catalytically Enhanced Type II-C Cas9 through Directed Protien Evolution
Yeast R2TP Interacts with Extended Termini of Client Protein Nop58p
The multistructural forms of box C/D ribonucleoprotein particles
Hematopoietic Progenitor Kinase-1 Structure in a Domain-Swapped Dimer
Directed evolution studies of a thermophilic Type II-C Cas9
Phosphate Lock Residues of <i>Acidothermus cellulolyticus</i> Cas9 Are Critical to Its Substrate Specificity