Area of research
Molecular Biology · Hematology
Research interest
Research interests include RNA Research and Splicing, Acute Myeloid Leukemia Research, Protein Degradation and Inhibitors, and Cancer-related molecular mechanisms research.
Epigenetic reactivation of the tumor suppressor ZBTB7A by KDM4 inhibition in human acute myeloid leukemia.
Mis-splicing-derived neoantigens and cognate TCRs in splicing factor mutant leukemias
HNRNPC and m6A RNA methylation control oncogenic transcription and metabolism in T-cell leukemia
Uncovering Novel lncRNAs Linked to Melanoma Growth and Migration with CRISPR Inhibition Screening.
An Isoform-Specific RUNX1C-BTG2 Axis Governs AML Quiescence and Chemoresistance.
Kinase-impaired BTK mutations are susceptible to clinical-stage BTK and IKZF1/3 degrader NX-2127
Altered RNA export by SF3B1 mutants confers sensitivity to nuclear export inhibition
Non-genetic mechanisms of drug resistance in acute leukemias.
Mis-Splicing Derived Neoantigens and Cognate T Cell Receptors in Splicing Factor Mutant Myeloid Neoplasms
Cell-type-specific prediction of 3D chromatin organization enables high-throughput in silico genetic screening
Modulation of RNA splicing enhances response to BCL2 inhibition in leukemia.
Mechanisms of Resistance to Noncovalent Bruton's Tyrosine Kinase Inhibitors.
The Impact of Inflammation-Induced Tumor Plasticity during Myeloid Transformation
The Impact of Inflammation-Induced Tumor Plasticity during Myeloid Transformation.
Valine tRNA levels and availability regulate complex I assembly in leukaemia.
NUDT21 limits CD19 levels through alternative mRNA polyadenylation in B cell acute lymphoblastic leukemia
NUDT21 limits CD19 levels through alternative mRNA polyadenylation in B cell acute lymphoblastic leukemia.
Impaired Proteolysis of Noncanonical RAS Proteins Drives Clonal Hematopoietic Transformation
Impaired Proteolysis of Noncanonical RAS Proteins Drives Clonal Hematopoietic Transformation.
Kinase Dead BTK Mutations Confer Resistance to Covalent and Noncovalent BTK Inhibitors but Are Susceptible to Clinical Stage BTK Degraders
Pharmacologic modulation of RNA splicing enhances anti-tumor immunity
Pharmacologic modulation of RNA splicing enhances anti-tumor immunity.
Minor intron retention drives clonal hematopoietic disorders and diverse cancer predisposition
Minor intron retention drives clonal hematopoietic disorders and diverse cancer predisposition.
Valine tRNA levels and availability regulate complex I assembly in leukaemia
Surface antigen-guided CRISPR screens identify regulators of myeloid leukemia differentiation
Surface antigen-guided CRISPR screens identify regulators of myeloid leukemia differentiation.
Posttranslational Regulation of the Exon Skipping Machinery Controls Aberrant Splicing in Leukemia