Area of research
Pulmonary and Respiratory Medicine · Cancer Research
Research interest
Research topics from publications: Ginsenoside Rb1 Enhances Atherosclerotic Plaque Stability by Improving Autophagy and Lipid Metabolism in Macrophage Foam Cells. Representative work: Atherosclerosis is a lipid-driven disease in which macrophage foam cells play a critical role by increasing vascular lipid accumulation and contributing to plaque instability. Ginsenoside Rb1 (Rb1), the most abundant active component of ginseng, was found potentially to promote lipid metabolism and attenuate lipid accumulation. However, the underlying mechanisms remain unclear. In this study, the effects of Rb1 on lipid accumulation and plaque stability were investigated both in vitro and in vivo by using primary peritoneal macrophages isolated from C57BL/6 mice and atherosclerosis model in ApoE-/- mice. The results showed that Rb1 reduced lipid accumulation both in macrophage foam cells and