Area of research
Hematology · Molecular Biology
Research interest
Research focused on Haematopoiesis and Leukemia, with related work in Cancer research, Stem cell, Wnt signaling pathway. Notable publications include 'Leukaemogenic effects of Ptpn11 activating mutations in the stem cell microenvironment', 'Sustained PU.1 Levels Balance Cell-Cycle Regulators to Prevent Exhaustion of Adult Hematopoietic Stem Cells', and 'A Transcription Factor Addiction in Leukemia Imposed by the MLL Promoter Sequence'.
A Transcription Factor Addiction in Leukemia Imposed by the MLL Promoter Sequence
Pathobiological Pseudohypoxia as a Putative Mechanism Underlying Myelodysplastic Syndromes
Leukaemogenic effects of Ptpn11 activating mutations in the stem cell microenvironment
Insertional Mutagenesis Identifies a STAT3/Arid1b/β-catenin Pathway Driving Neurofibroma Initiation
AF1q is a novel TCF7 co-factor which activates CD44 and promotes breast cancer metastasis
Regulation of AKT signaling by Id1 controls t(8;21) leukemia initiation and progression
Downregulation of RUNX1/CBFβ by MLL fusion proteins enhances hematopoietic stem cell self-renewal
Sustained PU.1 Levels Balance Cell-Cycle Regulators to Prevent Exhaustion of Adult Hematopoietic Stem Cells
PU.1 is essential for MLL leukemia partially via crosstalk with the MEIS/HOX pathway