Area of research
Epidemiology · Hepatology
Research interest
Research interests include Liver Disease Diagnosis and Treatment, Hepatitis B Virus Studies, Hepatocellular Carcinoma Treatment and Prognosis, and Hepatitis C virus research.
ALKBH5 deficiency suppresses hepatocarcinogenesis in mice via m<sup>6</sup>A-dependent STAT1 restoration.
Multi-omic analysis of gallbladder cancer identifies distinct tumor microenvironments associated with disease progression
Bile metabolic fingerprints distinguish biliary tract cancer from benign biliary diseases.
Circular RNA CDYL facilitates hepatocellular carcinoma stemness and PD-L1<sup>+</sup> exosomes-mediated immunotherapy resistance via stabilizing hornerin protein by blocking synoviolin 1-mediated ubiquitination.
Cell-free DNA testing for the detection and prognosis prediction of pancreatic cancer
Current status and prospects of targeted therapy for cholangiocarcinoma based on molecular characteristics.
Deciphering cholangiocarcinoma heterogeneity and specific progenitor cell niche of extrahepatic cholangiocarcinoma at single-cell resolution.
LTA4H improves the tumor microenvironment and prevents HCC progression via targeting the HNRNPA1/LTBP1/TGF-β axis.
Single-cell landscape of the intrahepatic ecosystem in alcohol-related liver disease.
Blocking the SIRPα-CD47 axis promotes macrophage phagocytosis of exosomes derived from visceral adipose tissue and improves inflammation and metabolism in mice.
HLF transactivates <i>TFEB</i> to promote gallbladder cancer stem cells' self-renewal and determines tumor response to distinct therapies.
Development of a nano-targeting chimera for the degradation of membrane and cytoplasmic proteins.
Single-cell analysis reveals CD34<sup>+</sup>CD90<sup>+</sup> endothelial cells promote tumor metastasis in gallbladder cancer.
Cell-free DNA testing for the detection and prognosis prediction of pancreatic cancer.
Multi-omic analysis of gallbladder cancer identifies distinct tumor microenvironments associated with disease progression.
Intranuclear paraspeckle-circular RNA TACC3 assembly forms RNA-DNA hybrids to facilitate MASH-related hepatocellular carcinoma growth in an m<sup>6</sup>A-dependent manner.
Hepatitis B virus integration and hepatocarcinogenesis.
Amelioration of Liver Fibrosis via In Situ Hepatic Stellate Cell Conversion Through Co-Inhibition of TGF-β and GSK-3 Signalling.
Hepatocellular Carcinoma Risk Stratification for Cirrhosis Patients: Integrating Radiomics and Deep Learning Computed Tomography Signatures of the Liver and Spleen into a Clinical Model.
PPP1R12B inhibits cell proliferation by inducing G0/G1 phase arrest via PAK2/β-catenin axis in hepatocellular carcinoma.
Single-cell sequencing and machine learning reveal the role of dioxin-interacting genes in HCC prognosis and immune microenvironment.
Investigating the shared genetic information between serum concentration levels of liver enzymes and cholelithiasis.
Comparative transcriptomic and genomic analysis of tumor cells in the marginal and center regions of tumor nests in human hepatocellular carcinoma.
The inwardly rectifying potassium channel KCNJ12 regulates the stemness of hepatocellular carcinoma cells through the Wnt/β-catenin pathway.
Traditional medicine Bazi Bushen potentiates immunosurveillance of senescent liver cancer cells via cGAS-STING signaling activation in macrophages.
The noncanonical function of liver-type phosphofructokinase potentiates the efficacy of HDAC inhibitors in cancer.
Construction and validation of consensus clustering-derived metabolism- and immune-associated genes model for prognosis prediction in cancer patients with liver metastases.
Deep whole-genome analysis of 494 hepatocellular carcinomas
Deep whole-genome analysis of 494 hepatocellular carcinomas.
TET2-mediated tumor cGAS triggers endothelial STING activation to regulate vasculature remodeling and anti-tumor immunity in liver cancer.