Area of research
Molecular Biology · Genetics
Research interest
Research interests include Virus-based gene therapy research, RNA Interference and Gene Delivery, CRISPR and Genetic Engineering, and Viral Infectious Diseases and Gene Expression in Insects.
The association between estimated glucose disposal rate and metabolic dysfunction-associated steatotic liver disease and liver fibrosis in US adults
rAAV capsid mutants eliminate leaky expression from DNA donor template for homologous recombination
Multiparametric MRI-based radiomic model for predicting lymph node metastasis after neoadjuvant chemoradiotherapy in locally advanced rectal cancer
rAAV capsid mutants eliminate leaky expression from DNA donor template for homologous recombination.
HIF1α/miR-146α/TRAF6/NF-κB axis modulates hepatic iron overload-induced inflammation.
Hypoxia-induced exosomes facilitate lung pre-metastatic niche formation in hepatocellular carcinoma through the miR-4508-RFX1-IL17A-p38 MAPK-NF-κB pathway.
The use of melittin to enhance transgene expression mediated by recombinant adeno-associated virus serotype 2 vectors both in vitro and in vivo.
Improved gene therapy for MFRP deficiency-mediated retinal degeneration by knocking down endogenous bicistronic Mfrp and Ctrp5 transcript
ROS-Activated TRPM2 Channel: Calcium Homeostasis in Cardiovascular/renal System and Speculation in Cardiorenal Syndrome
Improved gene therapy for MFRP deficiency-mediated retinal degeneration by knocking down endogenous bicistronic <i>Mfrp</i> and <i>Ctrp5</i> transcript.
Sphingosine-1-phosphate transporter spinster homolog 2 is essential for iron-regulated metastasis of hepatocellular carcinoma.
Sphingosine-1-phosphate transporter spinster homolog 2 is essential for iron-regulated metastasis of hepatocellular carcinoma
TiO2 NPs induce the reproductive toxicity in mice with gestational diabetes mellitus through the effects on the endoplasmic reticulum stress signaling pathway
AAV3-miRNA vectors for growth suppression of human hepatocellular carcinoma cells in vitro and human liver tumors in a murine xenograft model in vivo.
Low endotoxin <i>E. coli</i> strain-derived plasmids reduce rAAV vector-mediated immune responses both <i>in vitro</i> and <i>in vivo</i>.
The use of miR122 and its target sequence in adeno-associated virus-mediated trichosanthin gene therapy.
Mild iron overload induces TRIP12-mediated degradation of YY1 to trigger hepatic inflammation
Development of a Clinical Candidate AAV3 Vector for Gene Therapy of Hemophilia B
Development of a Clinical Candidate AAV3 Vector for Gene Therapy of Hemophilia B.
Mild iron overload induces TRIP12-mediated degradation of YY1 to trigger hepatic inflammation.
Enhanced Transduction of Human Hematopoietic Stem Cells by AAV6 Vectors: Implications in Gene Therapy and Genome Editing.
Site-Directed Mutagenesis Improves the Transduction Efficiency of Capsid Library-Derived Recombinant AAV Vectors.
Hepatocyte nuclear factor 4α negatively regulates connective tissue growth factor during liver regeneration.
Cellulose-based injectable hydrogel composite for pH-responsive and controllable drug delivery.
Gene manipulation in liver ductal organoids by optimized recombinant adeno-associated virus vectors.
TLR9-Activating CpG-B ODN but Not TLR7 Agonists Triggers Antibody Formation to Factor IX in Muscle Gene Transfer.
Rational Design of Gene Therapy Vectors.
Clinical Use of Toxic Proteins and Peptides from Tian Hua Fen and Scorpion Venom.
Chinese Medicine Protein and Peptide in Gene and Cell Therapy.
The hepatocyte-specific HNF4α/miR-122 pathway contributes to iron overload–mediated hepatic inflammation