Area of research
Physiology · Cellular and Molecular Neuroscience
Research interest
Research focused on Hyperphosphorylation and SUMO protein, with related work in CREB, Synucleinopathies, Disease. Notable publications include 'Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging', 'SUMOylation at K340 inhibits tau degradation through deregulating its phosphorylation and ubiquitination', and 'Tau accumulation induces synaptic impairment and memory deficit by calcineurin-mediated inactivation of nuclear CaMKIV/CREB signaling'.
Molecular mechanisms of mitochondrial quality control
LCN2 induces neuronal loss and facilitates sepsis-associated cognitive impairments
Age-related p53 SUMOylation accelerates senescence and tau pathology in Alzheimer’s disease
Aging-dependent YAP1 reduction contributes to AD pathology by upregulating the Nr4a1-AKT/GSK-3β axis
Age-dependent elevation of Nr4a1 attenuates PI3K/AKT/GSK3β pathway and mediates tau hyperphosphorylation and cognitive impairments
Abnormal protein post-translational modifications induces aggregation and abnormal deposition of protein, mediating neurodegenerative diseases
Generation of tau dephosphorylation-targeting chimeras for the treatment of Alzheimer’s disease and related tauopathies
A new tau dephosphorylation-targeting chimera for the treatment of tauopathies
TREM2 bridges microglia and extracellular microenvironment: Mechanistic landscape and therapeutical prospects on Alzheimer’s disease
Development of tau phosphorylation-targeting therapies for the treatment of neurodegenerative diseases
Social isolation impairs cognition via Aβ-mediated synaptic dysfunction
5-aminolevulinic acid photodynamic therapy inhibits the viability, invasion, and migration of cervical cancer SiHa cells by regulating the miR-152-3p/JAK1/STAT1 axis
Conformation pattern changes in R1-pS262 tau peptide induced endogenous tau aggregation, synaptic damage, and cognitive impairments
Development of an α-synuclein positron emission tomography tracer for imaging synucleinopathies
Bacteroides Fragilis in the gut microbiomes of Alzheimer’s disease activates microglia and triggers pathogenesis in neuronal C/EBPβ transgenic mice
Ferulic Acid Improves Synaptic Plasticity and Cognitive Impairments by Alleviating the PP2B/DARPP-32/PP1 Axis-Mediated STEP Increase and Aβ Burden in Alzheimer's Disease
Gypenoside IX restores Akt/GSK-3β pathway and alleviates Alzheimer’s disease-like neuropathology and cognitive deficits
C9orf72 <scp>poly‐PR</scp> helps p53 escape from the ubiquitin‐proteasome system and promotes its stability
Single‐nucleus transcriptome profiling of prefrontal cortex induced by chronic methamphetamine treatment
Glycogen Synthase Kinase-3β, NLRP3 Inflammasome, and Alzheimer’s Disease
c-Src regulates δ-secretase activation and truncated Tau production by phosphorylating the E3 ligase Traf6
Inactivation of ERK1/2-CREB Pathway Is Implicated in MK801-induced Cognitive Impairment
Human tau accumulation promotes glycogen synthase kinase-3β acetylation and thus upregulates the kinase: A vicious cycle in Alzheimer neurodegeneration
Defective mitophagy and the etiopathogenesis of Alzheimer’s disease
Tau Ubiquitination in Alzheimer's Disease
Neuronal C/EBPβ/AEP pathway shortens life span via selective GABAnergic neuronal degeneration by FOXO repression
HIF-1α Causes LCMT1/PP2A Deficiency and Mediates Tau Hyperphosphorylation and Cognitive Dysfunction during Chronic Hypoxia
USP10 deubiquitinates Tau, mediating its aggregation
Alzheimer’s Disease: From Pathogenesis to Mesenchymal Stem Cell Therapy – Bridging the Missing Link
SIRT1 deficiency increases O-GlcNAcylation of tau, mediating synaptic tauopathy