Area of research
Cancer Research · Cellular and Molecular Neuroscience
Research interest
Research topics from publications: MicroRNA-346 regulates neural stem cell proliferation and differentiation by targeting KLF4. Representative work: MicroRNAs have been shown to play an important role in stem cell fate determination and self-renewal. However, the role of miRNAs in neural stem cells (NSCs) remains poorly understood. In this study, we showed that miR-346, a less characterized microRNA, promoted NSCs proliferation, differentiation and apoptosis by targeting KLF4, a core transcriptional factor in stem cell fate determination. Our data suggested that miR-346 could directly target the 3'-untranslated region of KLF4. Overexpression of miR-346 decreased KLF4 expression at both mRNA and protein levels in NSCs. More importantly, Overexpression of miR-346 repressed NSC proliferation and induced the expression of lineage markers inc