Gongliang Du

Area of research

Cancer Research · Molecular Biology

Research interest

Research topics from publications: piRNA-36741 regulates BMP2-mediated osteoblast differentiation via METTL3 controlled m6A modification; Peroxisome proliferator‐activated receptor gamma coactivator‐1α/HSF1 axis effectively alleviates lipopolysaccharide‐induced acute lung injury via suppressing oxidative stress and inflammatory response; Leptin-elicited miRNA-342-3p potentiates gemcitabine resistance in pancreatic ductal adenocarcinoma; Irisin attenuates lipopolysaccharide-induced acute lung injury by downregulating inflammatory cytokine expression through miR-199a-mediated Rad23b overexpression; S100B ranks as a new marker of multiple traumas in patients and may accelerate its development by regulating endothelial cell dysfunction; Comparative gene expression profiling of normal and human colorectal adenomatous tissues; Effect of Urolithin A on Bone Repair in Mice with Bone Defects. Representative work: The osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) is essential for bone formation, and its imbalance can lead to bone diseases such as osteoporosis. It is reported that PIWI-interacting RNA-36741 (piR-36741) is up-regulated during the osteogenic differentiation, but its role in regulating osteogenic differentiation remains unclear. Here, the primary human BMSCs were used to induce osteogenic differentiation, and the expression of piR-36741 and METTL3 (methyltransferase like 3) was up-regulated during the osteogenic differentiation of BMSCs. Moreover, interference with piR-36741 or METTL3 markedly hindered the osteogenic differentiation of BMSCs, which was manifeste Abstract Acute lung injury (ALI) interferes with lung function by causing pulmonary inflammation and oxidative stress. Suppressing intracellular reactive oxygen species (ROS) may block intracellular inflammation. Thus, the purpose of the current study was to investigate the roles of peroxisome proliferator‐activated receptor gamma coactivator‐1α (PGC1α)/HSF1 axis in an lipopolysaccharide (LPS)‐induced ALI murine model and in RAW264.7 macrophages. In the LPS‐administrated mouse model, the addition of PGC1α obviously ameliorated secretion of pro‐inflammatory mediators tumor necrosis factor‐α and Interleukin 6 as well as MCP‐1 expression triggered by LPS stimulation, accompanied with reduced in