Shan Ding

Area of research

Biomedical Engineering · Biomaterials

Research interest

Research topics from publications: Dual drug loaded coaxial electrospun PLGA/PVP fiber for guided tissue regeneration under control of infection; 3D poly (L-lactide)/chitosan micro/nano fibrous scaffolds functionalized with quercetin-polydopamine for enhanced osteogenic and anti-inflammatory activities; Mechanical properties and osteogenic activity of poly(l-lactide) fibrous membrane synergistically enhanced by chitosan nanofibers and polydopamine layer; Strengthening and toughening of poly(L-lactide) composites by surface modified MgO whiskers; Preparation of chitin/MXene/poly(L-arginine) composite aerogel spheres for specific adsorption of bilirubin; Chitin whisker/chitosan liquid crystal hydrogel assisted scaffolds with bone-like ECM microenvironment for bone regeneration; A Tough Janus Hydrogel Patch with Strong Wet Adhesion and Self-Debonding for Oral Ulcer Treatment; Bone ECM-inspired biomineralization chitin whisker liquid crystal hydrogels for bone regeneration; Modulating of Bouligand Structure and Chirality Constructed Bionically Based on the Self-Assembly of Chitin Whiskers; Abundant nucleation sites-available liquid crystal hydrogel mimics bone ECM mineralization to boost osteogenesis. Representative work: Oral ulcers (OU) are the most common oral mucosal disease in humans across all geographic regions, seriously affecting patients’ quality of life and even leading to irreversible loss of function. Existing clinical treatments, such as ointments, sprays, and oral patches, are often washed out by saliva within a few hours, posing challenges for dentists. Adhesive hydrogel dressings show promise to address these issues, but existing options lack wet adhesion, flexibility, and gentle debonding, limiting their application in dynamic wet environments like the oral cavity. To overcome these limitations, a hydrogen-bond-based Janus hydrogel patch was developed. N-[Tris(hydroxymethyl)methyl]-acrylamid Chitin can self-assemble into a liquid crystal phase with supramolecular chirality and Bouligand structure, which is widely found in the exoskeletons of arthropods. However, bionically replicating this structure via the self-assembly of chitin whiskers (CHWs) is still a challenge. Here, the effects of several internal and external parameters on the self-assembly of CHWs were revealed based on liquid crystal phase, chirality, Bouligand structure, and rheolog