Area of research
Toxicology · Cancer Research
Research interest
Research topics from publications: A label-free fluorescent aptasensor for AFB1 and AFM1 based on the aptamer tailoring strategy and synergistic signal amplification of HCR and MoS2 nanosheets; Systematic Characterization of In Vitro and In Vivo Metabolic Pathways and Identification of Novel Biomarkers of 26 Synthetic Cannabinoids. Representative work: In recent years, the harms and abuse of synthetic cannabinoids (SCs) have attracted extensive attention in society. Their structures have been updated rapidly, which brings great challenges for continuous detection and drug identification. The aim of this study was to elucidate the metabolites of 26 kinds of abused SCs produced in human liver microsomes (HLMs) and rats and to explore the metabolism of indole amides, indazole amides, azaindoles, naphthyl indoles, cyclopropylindoles, naphthyl benzimidazole, and naphthyl pyrrole SCs in vivo and in vitro. Human liver microsomes were incubated with SCs to simulate human metabolic processes, and the in vitro metabolic model of liver microsomes was