Area of research
Molecular Biology · Pulmonary and Respiratory Medicine
Research interest
Research interests include Epigenetics and DNA Methylation, RNA modifications and cancer, Prostate Cancer Treatment and Research, and Protein Degradation and Inhibitors.
Size-dependent internalization of polystyrene microplastics as a key factor in macrophages and systemic toxicity
Small protein ERSP encoded by LINC02870 promotes triple negative breast cancer progression via IRE1α/XBP1s activation
1848MO Phase II study of firmonertinib in patients with previously treated advanced/metastatic non-small cell lung cancer (mNSCLC) with EGFR exon 20 insertion (ex20ins) mutations
An integrated multi-tissue atlas of epigenomic landscapes and regulatory elements in the bovine genome
UMP functions as an endogenous regulator of NR4A1 to control gastric cancer progression
An integrated multi-tissue atlas of epigenomic landscapes and regulatory elements in the bovine genome
Discovery of highly potent marine-derived compound Penicolinate H reveals SREBP-1 mediated lipogenesis as a druggable vulnerability in gastric cancer
DHODH inhibition represents a therapeutic strategy and improves abiraterone treatment in castration-resistant prostate cancer
Design, Synthesis, and Biological Evaluation of Novel Diaminopyrimidine Macrocycles as Fourth Generation Reversible EGFR Inhibitors That Overcome Clinical Resistance to Osimertinib Mediated by C797S Mutation
Tumor mitochondrial oxidative phosphorylation stimulated by the nuclear receptor RORγ represents an effective therapeutic opportunity in osteosarcoma
Corrigendum to “Arctiin abrogates osteoclastogenesis and bone resorption via suppressing RANKL-induced ROS and NFATc1 activation” [Pharmacol. Res. 159 (2020) 104944]
Wild-type IDH1 maintains NSCLC stemness and chemoresistance through activation of the serine biosynthetic pathway
Inhibition of STAT3-ferroptosis negative regulatory axis suppresses tumor growth and alleviates chemoresistance in gastric cancer
Targeting autophagy peptidase ATG4B with a novel natural product inhibitor Azalomycin F4a for advanced gastric cancer
Kynurenine-3-monooxygenase (KMO) broadly inhibits viral infections via triggering NMDAR/Ca2+ influx and CaMKII/ IRF3-mediated IFN-β production
Rorγ Targeting Promotes Apoptosis and Ferroptosis in Osteosarcoma by Reprogramming Mitochondrial Oxidative Phosphorylation
The m6A demethylase FTO promotes the osteogenesis of mesenchymal stem cells by downregulating PPARG
Exploring Marine-Derived Ascochlorins as Novel Human Dihydroorotate Dehydrogenase Inhibitors for Treatment of Triple-Negative Breast Cancer
Cyclopentenone-Containing Tetrahydroquinoline and Geldanamycin Alkaloids from <i>Streptomyces malaysiensis</i> as Potential Anti-Androgens against Prostate Cancer Cells
Ilicicolin A Exerts Antitumor Effect in Castration-Resistant Prostate Cancer Via Suppressing EZH2 Signaling Pathway
TRIB3-EGFR interaction promotes lung cancer progression and defines a therapeutic target
T Cells Expressing NKG2D CAR with a DAP12 Signaling Domain Stimulate Lower Cytokine Production While Effective in Tumor Eradication
Arctiin abrogates osteoclastogenesis and bone resorption via suppressing RANKL-induced ROS and NFATc1 activation
The poly(ADP-ribosyl)ation of BRD4 mediated by PARP1 promoted pathological cardiac hypertrophy
Histone Demethylase JMJD3 Mediated Doxorubicin-Induced Cardiomyopathy by Suppressing SESN2 Expression
S-adenosylhomocysteine (AdoHcy)-dependent methyltransferase inhibitor DZNep overcomes breast cancer tamoxifen resistance via induction of NSD2 degradation and suppression of NSD2-driven redox homeostasis
Histone H4R3 symmetric di-methylation by Prmt5 protects against cardiac hypertrophy via regulation of Filip1L/β-catenin
Cytotoxic benzopyranone and xanthone derivatives from a coral symbiotic fungus <i>Cladosporium halotolerans</i> GXIMD 02502
Orphan nuclear receptor RORγ confers doxorubicin resistance in prostate cancer
RORγ is a targetable master regulator of cholesterol biosynthesis in a cancer subtype