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Lee M

National University of Singapore · SG
Area of research
Public Health, Environmental and Occupational Health · Computational Theory and Mathematics
Research interest
Research focused on Malaria and Plasmodium falciparum, with related work in Druggability, Drug discovery, Plasmodium (life cycle). Notable publications include 'A novel multiple-stage antimalarial agent that inhibits protein synthesis', 'Targeting Plasmodium PI(4)K to eliminate malaria', and 'Mapping the malaria parasite druggable genome by using in vitro evolution and chemogenomics'.
h-index
citations
3,024
works
31
NIH funding
primary concept
email

Recent publications

Revisiting the Plasmodium falciparum druggable genome using predicted structures and data mining
npj Drug Discovery. 2025cited by 10position: middledoi
Optimization and Characterization of N-Acetamide Indoles as Antimalarials That Target PfATP4
Journal of Medicinal Chemistry 2025cited by 6position: middledoi
Drug resistance–associated mutations in Plasmodium UBP-1 disrupt its essential deubiquitinating activity
Journal of Biological Chemistry 2025cited by 3position: middledoi
Optimization and Characterization of the Antimalarial Activity of <i>N</i>-Aryl Acetamides that are Susceptible to Mutations in ROM8 and CSC1
Journal of Medicinal Chemistry 2025cited by 3position: middledoi
Quinoxaline-based anti-schistosomal compounds have potent anti-plasmodial activity
PLoS Pathogens 2025cited by 3position: lastdoi
Targeting Aurora Kinases as Essential Cell‐Cycle Regulators to Deliver Multi‐Stage Antimalarials Against <i>Plasmodium Falciparum</i>
Angewandte Chemie International Edition 2025cited by 2position: middledoi
2,8-Disubstituted-1,5-naphthyridines as Dual Inhibitors of <i>Plasmodium falciparum</i> Phosphatidylinositol-4-kinase and Hemozoin Formation with <i>In Vivo</i> Efficacy
Journal of Medicinal Chemistry 2024cited by 20position: middledoi
Systematic in vitro evolution in <i>Plasmodium falciparum</i> reveals key determinants of drug resistance
Science 2024cited by 18position: middledoi
β-Carboline-3-carboxamide Antimalarials: Structure–Activity Relationship, ADME-Tox Studies, and Resistance Profiling
ACS Infectious Diseases 2024cited by 5position: middledoi
Quinoxaline-Based Anti-Schistosomal Compounds Have Potent Anti-Malarial Activity
bioRxiv (Cold Spring Harbor Laboratory) 2024cited by 2position: lastdoi
Generation of a mutator parasite to drive resistome discovery in Plasmodium falciparum
Nature Communications 2023cited by 44position: lastdoi
Reaction hijacking of tyrosine tRNA synthetase as a new whole-of-life-cycle antimalarial strategy
Science 2022cited by 55position: middledoi
Integrative Genetic Manipulation of <i>Plasmodium cynomolgi</i> Reveals Multidrug Resistance-1 Y976F Associated With Increased In Vitro Susceptibility to Mefloquine
The Journal of Infectious Diseases 2022cited by 26position: middledoi
The effect of cold water immersion on the recovery of physical performance revisited: A systematic review with meta-analysis
Journal of Sports Sciences 2022cited by 26position: middledoi
MalDA, Accelerating Malaria Drug Discovery
Trends in Parasitology 2021cited by 115position: middledoi
Prioritization of Molecular Targets for Antimalarial Drug Discovery
ACS Infectious Diseases 2021cited by 84position: middledoi
Chemogenomics identifies acetyl-coenzyme A synthetase as a target for malaria treatment and prevention
Cell chemical biology 2021cited by 80position: middledoi
3D bioprinting and microscale organization of vascularized tissue constructs using collagen‐based bioink
Biotechnology and Bioengineering 2021cited by 52position: middledoi
Inhibition of Resistance-Refractory P. falciparum Kinase PKG Delivers Prophylactic, Blood Stage, and Transmission-Blocking Antiplasmodial Activity
Cell chemical biology 2020cited by 90position: middledoi
Pan-active imidazolopiperazine antimalarials target the Plasmodium falciparum intracellular secretory pathway
Nature Communications 2020cited by 53position: middledoi
Combining Stage Specificity and Metabolomic Profiling to Advance Antimalarial Drug Discovery
Cell chemical biology 2019cited by 94position: middledoi
Mapping the malaria parasite druggable genome by using in vitro evolution and chemogenomics
Science 2018cited by 273position: middledoi
A potent antimalarial benzoxaborole targets a Plasmodium falciparum cleavage and polyadenylation specificity factor homologue
Nature Communications 2017cited by 142position: middledoi
UDP-galactose and acetyl-CoA transporters as Plasmodium multidrug resistance genes
Nature Microbiology 2016cited by 147position: middledoi
A broad analysis of resistance development in the malaria parasite
Nature Communications 2016cited by 131position: middledoi
CRISPR‐Cas9‐modified <i>pfmdr1</i> protects <i>Plasmodium falciparum</i> asexual blood stages and gametocytes against a class of piperazine‐containing compounds but potentiates artemisinin‐based combination therapy partner drugs
Molecular Microbiology 2016cited by 68position: middledoi
A novel multiple-stage antimalarial agent that inhibits protein synthesis
Nature 2015cited by 463position: middledoi
Profiling the Essential Nature of Lipid Metabolism in Asexual Blood and Gametocyte Stages of Plasmodium falciparum
Cell Host & Microbe 2015cited by 181position: middledoi
(+)-SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance of <i>Plasmodium</i>
Proceedings of the National Academy of Sciences 2014cited by 247position: middledoi
KAF156 Is an Antimalarial Clinical Candidate with Potential for Use in Prophylaxis, Treatment, and Prevention of Disease Transmission
Antimicrobial Agents and Chemotherapy 2014cited by 158position: middledoi

Grants

No grants ingested yet.

Frequent collaborators

David A. Fidock · Universidade Federal de Rondônia11 papers (2015–2025)Elizabeth A. Winzeler · University of California San Diego7 papers (2016–2025) · 4 papers (2017–2023)Sabine Ottilie · Scripps Research Institute3 papers (2019–2021)John Okombo · University of Cape Town3 papers (2021–2025)Daniel E. Goldberg · University of Arizona3 papers (2019–2021)Tomas Yeo · Nanyang Technological University3 papers (2023–2025)Jacquin C. Niles · Massachusetts Institute of Technology3 papers (2021–2025)Mukul Rawat · University of Dundee3 papers (2023–2025)Eva S. Istvan · Washington University in St. Louis3 papers (2019–2021)Koen J. Dechering · London School of Hygiene & Tropical Medicine2 papers (2021–2021)Johanna Hoshizaki · McGill University2 papers (2023–2025)Charisse Flerida A. Pasaje · Massachusetts Institute of Technology2 papers (2021–2025)Dyann F. Wirth · Broad Institute2 papers (2021–2021) · 2 papers (2021–2021)Gilda Padalino · Swansea University2 papers (2024–2025)Manuel Llinás · Princeton University2 papers (2019–2021)Ian H. Gilbert · University of Dundee2 papers (2021–2021)Case W. McNamara · Scripps Institution of Oceanography2 papers (2021–2021)Susan Wyllie · University of Dundee2 papers (2021–2021)