Area of research
Pharmacology · Cancer Research
Research interest
Research interests include Pharmacogenetics and Drug Metabolism, Drug Transport and Resistance Mechanisms, Cancer, Lipids, and Metabolism, and Berberine and alkaloids research.
Present progress in biomarker discovery of endometrial cancer by multi-omics approaches
Baicalein specifically suppresses microsatellite instability colorectal cancer by targeting adenosylhomocysteinase to inhibit histone H3 lysine 4 trimethylation-mediated cancer stemness
CYP3A4 and MRP2 are predominant metabolic regulators attribute to the toxicity/efficacy of aconitine derived from Fuzi
Pharmacoepigenetics of Chinese herbal components in cancer
Tumor mitochondrial oxidative phosphorylation stimulated by the nuclear receptor RORγ represents an effective therapeutic opportunity in osteosarcoma
HBB contributes to individualized aconitine-induced cardiotoxicity in mice via interfering with ABHD5/AMPK/HDAC4 axis
The potential role of tumor deposits in the prognosis and TNM staging for colorectal cancer
Integrative Analysis of Multi-Omic Data for the Characteristics of Endometrial Cancer
Depletion of regulatory T cells enhancing the anti-tumor effect of in situ vaccination in solid tumors
Sinomenine ameliorates collagen-induced arthritis in mice by targeting GBP5 and regulating the P2X7 receptor to suppress NLRP3-related signaling pathways
Pharmacological mechanisms of sinomenine in anti-inflammatory immunity and osteoprotection in rheumatoid arthritis: A systematic review
Bile acids promote the development of HCC by activating the inflammasome
Salvianolic acid F suppresses KRAS-dependent lung cancer cell growth through the PI3K/AKT signaling pathway
Peripheral Circulating Exosomal-miRNAs Potentially Mediate the Sensitivity to Interferon Treatment in Chronic Hepatitis B Virus Patients
Artesunate Inhibits the Cell Growth in Colorectal Cancer by Promoting ROS-Dependent Cell Senescence and Autophagy
The mechanism of dioscin preventing lung cancer based on network pharmacology and experimental validation
c-Myc-PD-L1 Axis Sustained Gemcitabine-Resistance in Pancreatic Cancer
Alcohol triggered bile acid disequilibrium by suppressing BSEP to sustain hepatocellular carcinoma progression
Integrated network pharmacology and DSS-induced colitis model to determine the anti-colitis effect of Rheum palmatum L. and Coptis chinensis Franch in granules
Rorγ Targeting Promotes Apoptosis and Ferroptosis in Osteosarcoma by Reprogramming Mitochondrial Oxidative Phosphorylation
Integrated Network Pharmacology and DSS-Induced Colitis Model to Determine the Anti-Colitis Effect of Herbal Pair AMK-PLP
Sinomenine protects bone from destruction to ameliorate arthritis via activating p62Thr269/Ser272-Keap1-Nrf2 feedback loop
miR-7/TGF-β2 axis sustains acidic tumor microenvironment-induced lung cancer metastasis
The novel FAT4 activator jujuboside A suppresses NSCLC tumorigenesis by activating HIPPO signaling and inhibiting YAP nuclear translocation
Disordered farnesoid <scp>X</scp> receptor signaling is associated with liver carcinogenesis in <scp><i>Abcb11</i></scp>‐deficient mice
IKKβ mediates homeostatic function in inflammation via competitively phosphorylating AMPK and IκBα
Screening tumor specificity targeted by arnicolide D, the active compound of Centipeda minima and molecular mechanism underlying by integrative pharmacology
Ras inhibitor farnesylthiosalicylic acid conjugated with IR783 dye exhibits improved tumor-targeting and altered anti-breast cancer mechanisms in mice
Construction and immunogenic studies of a mFc fusion receptor binding domain (RBD) of spike protein as a subunit vaccine against SARS-CoV-2 infection
Evodiamine suppresses Notch3 signaling in lung tumorigenesis via direct binding to γ-secretases