Area of research
Biotechnology · Cancer Research
Research interest
Research topics from publications: The RNA m6A writer WTAP in diseases: structure, roles, and mechanisms; Non-coding small nucleolar RNA SNORD17 promotes the progression of hepatocellular carcinoma through a positive feedback loop upon p53 inactivation. Representative work: Abstract N6-methyladenosine (m 6 A) is a widely investigated RNA modification in studies on the “epigenetic regulation” of mRNAs that is ubiquitously present in eukaryotes. Abnormal changes in m 6 A levels are closely related to the regulation of RNA metabolism, heat shock stress, tumor occurrence, and development. m 6 A modifications are catalyzed by the m 6 A writer complex, which contains RNA methyltransferase-like 3 (METTL3), methyltransferase-like 14 (METTL14), Wilms tumor 1-associated protein (WTAP), and other proteins with methyltransferase (MTase) capability, such as RNA-binding motif protein 15 (RBM15), KIAA1429 and zinc finger CCCH-type containing 13 (ZC3H13). Although METTL3 is th