Area of research
Hepatology · Epidemiology
Research interest
Research interests include Liver Diseases and Immunity, Liver Disease Diagnosis and Treatment, Pediatric Hepatobiliary Diseases and Treatments, and Drug Transport and Resistance Mechanisms.
Network meta-analysis: relative clinical efficacy and safety of elafibranor versus seladelpar as second-line treatment for patients with primary biliary cholangitis.
Optimising Primary thErapy in pRimAry biliary cholangitis (OPERA): protocol for a randomised, double-blind, placebo-controlled trial of enhanced primary therapy with obeticholic acid.
Long-Term Efficacy and Safety of Selective PPARδ Agonist Seladelpar in Primary Biliary Cholangitis: ASSURE Interim Study Results
Primary biliary cholangitis drug evaluation and regulatory approval: Where do we go from here?
Relationship between pruritus and sleep in participants with primary biliary cholangitis in the Phase 2b GLIMMER trial
Efficacy and Safety of Elafibranor in Primary Biliary Cholangitis
Adequate versus deep response to ursodeoxycholic acid in primary biliary cholangitis: To what extent and under what conditions is normal alkaline phosphatase level associated with complication-free survival gain?
Setanaxib, a first‐in‐class selective NADPH oxidase 1/4 inhibitor for primary biliary cholangitis: A randomized, placebo‐controlled, phase 2 trial
Seladelpar treatment reduces IL-31 and pruritus in patients with primary biliary cholangitis
Open‐label, clinical trial extension: Two‐year safety and efficacy results of seladelpar in patients with primary biliary cholangitis
Impact of setanaxib on quality of life outcomes in primary biliary cholangitis in a phase 2 randomized controlled trial
Impact of setanaxib on quality of life outcomes in primary biliary cholangitis in a phase 2 randomized controlled trial.
Critical shortfalls in the management of PBC: Results of a UK-wide, population-based evaluation of care delivery
Regulation of immune responses in primary biliary cholangitis: a transcriptomic analysis of peripheral immune cells.
Greater Transplant-Free Survival in Patients Receiving Obeticholic Acid for Primary Biliary Cholangitis in a Clinical Trial Setting Compared to Real-World External Controls
GLIMMER: A Randomized Phase 2b Dose-Ranging Trial of Linerixibat in Primary Biliary Cholangitis Patients With Pruritus
Farnesoid X receptor agonist tropifexor attenuates cholestasis in a randomised trial in patients with primary biliary cholangitis
An international genome-wide meta-analysis of primary biliary cholangitis: Novel risk loci and candidate drugs
A randomized placebo-controlled trial of elafibranor in patients with primary biliary cholangitis and incomplete response to UDCA
Seladelpar improved measures of pruritus, sleep, and fatigue and decreased serum bile acids in patients with primary biliary cholangitis
TGF-β2 silencing to target biliary-derived liver diseases
Effects of Primary Biliary Cholangitis on Quality of Life and Health Care Costs in the United Kingdom
British Society of Gastroenterology and UK-PSC guidelines for the diagnosis and management of primary sclerosing cholangitis
The challenges of primary biliary cholangitis: What is new and what needs to be done
A Randomized, Controlled, Phase 2 Study of Maralixibat in the Treatment of Itching Associated With Primary Biliary Cholangitis
Fatigue in chronic liver disease: New insights and therapeutic approaches.
PBC‐10: a short quality of life measure for clinical screening in primary biliary cholangitis
Editorial: rapid assessment of health‐related quality of life in primary biliary cholangitis—no excuse not to ask. Authors' reply
Pretreatment prediction of response to ursodeoxycholic acid in primary biliary cholangitis: development and validation of the UDCA Response Score
Seladelpar (MBX-8025), a selective PPAR-δ agonist, in patients with primary biliary cholangitis with an inadequate response to ursodeoxycholic acid: a double-blind, randomised, placebo-controlled, phase 2, proof-of-concept study
Collaborative Research: The Connection between Astrophysical Transients and their Host Galaxies Across Cosmic Time
EPSCoR Research Fellows: NSF: Building a Duke University and University of Hawaii Collaboration for the Next Decade of Supernova Cosmology
Cosmology in the Local Volume with Hawai'i Supernova Flows
Statewide effort to diversify undergraduate engineering student population.
Strengthening Transitions into Engineering Programs
Connection to PREPnet/NSFNET for Gwynedd-Mercy College
Segmental Integration of Spinal Cord Descending 5HT and NE Neuron Function
Comprehensive Assistance to Undergraduate Science Education