Area of research
Pulmonary and Respiratory Medicine · Physiology
Research interest
Research interests include Chronic Obstructive Pulmonary Disease (COPD) Research, Pulmonary Hypertension Research and Treatments, Respiratory Support and Mechanisms, and Asthma and respiratory diseases.
Two randomised controlled phase 2 studies of the oral neutrophil elastase inhibitor alvelestat in alpha-1 antitrypsin deficiency
Neutrophil-to-Lymphocyte Ratio as a Biomarker in Clinically Stable Chronic Obstructive Pulmonary Disease: SPIROMICS Cohort
Maternal smoking and CC-16: implications for lung development and COPD across the lifespan
Pulmonary vascular features on chest computed tomography differentially associate with adverse outcomes in smokers in COPDGene
Spatial Transcriptomic Approach to Understanding Coronary Atherosclerotic Plaque Stability
What every clinician should know about inflammation in COPD
Differential Association of COPD Subtypes With Cardiovascular Events and COPD Exacerbations
A Research Agenda to Improve Outcomes in Patients with Chronic Obstructive Pulmonary Disease and Cardiovascular Disease: An Official American Thoracic Society Research Statement
Design of the SPIROMICS Study of Early COPD Progression: SOURCE Study
Alvelestat (MPH966) for the Treatment of Alpha-1 Antitrypsin Deficiency (ATALANTa): A Phase 2, Multicenter, Double-blind, Randomized, Placebo-controlled Study to Evaluate Efficacy, Safety, and Tolerability of Alvelestat in Alpha-1 Antitrypsin Deficiency
Causes of and Clinical Features Associated with Death in Tobacco Cigarette Users by Lung Function Impairment
Protease-armed, Pathogenic Extracellular Vesicles Link Smoking and Chronic Obstructive Pulmonary Disease
A blood and bronchoalveolar lavage protein signature of rapid FEV1 decline in smoking-associated COPD
Preserved Ratio With Impaired Spirometry
Forced Expiratory Flow at 25%-75% Links COPD Physiology to Emphysema and Disease Severity in the SPIROMICS Cohort
Mortality Risk and Serious Cardiopulmonary Events in Moderate-to-Severe COPD: Post Hoc Analysis of the IMPACT Trial
Bronchodilator Responsiveness in Tobacco-Exposed People With or Without COPD
Clinical risk factors for admission with Pseudomonas and multidrug-resistant Pseudomonas community-acquired pneumonia
Lung microbiota associations with clinical features of COPD in the SPIROMICS cohort
Secondary polycythemia in chronic obstructive pulmonary disease: prevalence and risk factors
Pulmonary Arterial Pruning and Longitudinal Change in Percent Emphysema and Lung Function
Identification of Sputum Biomarkers Predictive of Pulmonary Exacerbations in COPD
Significance of FEV3/FEV6 in Recognition of Early Airway Disease in Smokers at Risk of Development of COPD
Small Airway Disease and Emphysema Are Associated with Future Exacerbations in Smokers with CT-derived Bronchiectasis and COPD: Results from the COPDGene Cohort
Association of plasma mitochondrial DNA with COPD severity and progression in the SPIROMICS cohort
ST6GAL1 and α2-6 Sialylation Regulates IL-6 Expression and Secretion in Chronic Obstructive Pulmonary Disease
Genetic variation in genes regulating skeletal muscle regeneration and tissue remodelling associated with weight loss in chronic obstructive pulmonary disease
Prolyl endopeptidase contributes to early neutrophilic inflammation in acute myocardial transplant rejection
Machine Learning and Prediction of All-Cause Mortality in COPD
Associations Among 25-Hydroxyvitamin D Levels, Lung Function, and Exacerbation Outcomes in COPD