Area of research
Hematology · Genetics
Research interest
Research interests include Blood Coagulation and Thrombosis Mechanisms, Venous Thromboembolism Diagnosis and Management, Coagulation, Bradykinin, Polyphosphates, and Angioedema, and Vitamin K Research Studies.
Lipid presentation by the protein C receptor links coagulation with autoimmunity
Aging Reprograms the Hematopoietic-Vascular Niche to Impede Regeneration and Promote Fibrosis
Podocyte Integrin-β 3 and Activated Protein C Coordinately Restrict RhoA Signaling and Ameliorate Diabetic Nephropathy
Effect of a Recombinant Human Soluble Thrombomodulin on Mortality in Patients With Sepsis-Associated Coagulopathy
Cerebral cavernous malformations form an anticoagulant vascular domain in humans and mice
Platelets and neutrophil extracellular traps collaborate to promote intravascular coagulation during sepsis in mice
The Role of Extracellular Histones in Influenza Virus Pathogenesis
Signal integration at the PI3K-p85-XBP1 hub endows coagulation protease activated protein C with insulin-like function
Regulation of long‐term repopulating hematopoietic stem cells by EPCR/PAR1 signaling
PAR1 signaling regulates the retention and recruitment of EPCR-expressing bone marrow hematopoietic stem cells
Activated Protein C Ameliorates Renal Ischemia-Reperfusion Injury by Restricting Y-Box Binding Protein-1 Ubiquitination
Baboon Model of Escherichia coli Sepsis: Description of its Four Stages and the Role of Tumor Necrosis Factor, Tissue Factors, and the Protein C System in Septic Shock1
Roles of Coagulation and Fibrinolysis in Angiotensin <scp>II</scp>‐Enhanced Microvascular Thrombosis
Factor VIIa binding to endothelial cell protein C receptor protects vascular barrier integrity in vivo
A Randomized, Double-Blind, Placebo-Controlled, Phase 2b Study to Evaluate the Safety and Efficacy of Recombinant Human Soluble Thrombomodulin, ART-123, in Patients With Sepsis and Suspected Disseminated Intravascular Coagulation*
Histones Activate the NLRP3 Inflammasome in Kupffer Cells during Sterile Inflammatory Liver Injury
Loss of endothelial protein C receptors links coagulation and inflammation to parasite sequestration in cerebral malaria in African children
Genetic and Pharmacological Modifications of Thrombin Formation in Apolipoprotein E-deficient Mice Determine Atherosclerosis Severity and Atherothrombosis Onset in a Neutrophil-Dependent Manner
Molecular circuits in thrombosis and inflammation
Protein C and acute inflammation: a clinical and biological perspective
Endothelial Protein C Receptor Function in Murine and Human Breast Cancer Development
Vascular Immunotargeting to Endothelial Determinant ICAM-1 Enables Optimal Partnering of Recombinant scFv-Thrombomodulin Fusion with Endogenous Cofactor
Structural and Functional Studies of γ-Carboxyglutamic Acid Domains of Factor VIIa and Activated Protein C: Role of Magnesium at Physiological Calcium
Inhibition of Endogenous Activated Protein C Attenuates Experimental Autoimmune Encephalomyelitis by Inducing Myeloid-Derived Suppressor Cells
Rab GTPases Regulate Endothelial Cell Protein C Receptor-Mediated Endocytosis and Trafficking of Factor VIIa
Overexpression of the Endothelial Protein C Receptor Is Detrimental during Pneumonia-Derived Gram-negative Sepsis (Melioidosis)
Platelet Endothelial Cell Adhesion Molecule Targeted Oxidant-Resistant Mutant Thrombomodulin Fusion Protein with Enhanced Potency In Vitro and In Vivo
Activated protein C ameliorates diabetic nephropathy by epigenetically inhibiting the redox enzyme p66 <sup>Shc</sup>
Targeting recombinant thrombomodulin fusion protein to red blood cells provides multifaceted thromboprophylaxis
Endothelial cell protein C receptor‐mediated redistribution and tissue‐level accumulation of factor VIIa