Area of research
Molecular Biology
Research interest
Research focused on Neurodegeneration and Endoderm, with related work in Neuroscience, Embryonic stem cell, Neurogenesis. Notable publications include 'The Long Noncoding RNA RMST Interacts with SOX2 to Regulate Neurogenesis', 'Long noncoding RNAs in development and disease of the central nervous system', and 'Widespread binding of FUS along nascent RNA regulates alternative splicing in the brain'.
A Balanced Translocation in Kallmann Syndrome Implicates a Long Noncoding RNA, RMST, as a GnRH Neuronal Regulator
Genetic Correction of SOD1 Mutant iPSCs Reveals ERK and JNK Activated AP1 as a Driver of Neurodegeneration in Amyotrophic Lateral Sclerosis
Molecular Features Underlying Neurodegeneration Identified through In Vitro Modeling of Genetically Diverse Parkinson’s Disease Patients
Establishing Criteria for Human Mesenchymal Stem Cell Potency
Reinforcement of STAT3 activity reprogrammes human embryonic stem cells to naive-like pluripotency
NeuO: a Fluorescent Chemical Probe for Live Neuron Labeling
Chromatin and RNA Maps Reveal Regulatory Long Noncoding RNAs in Mouse
APP intracellular domain acts as a transcriptional regulator of miR-663 suppressing neuronal differentiation
MiR-375 is Essential for Human Spinal Motor Neuron Development and May Be Involved in Motor Neuron Degeneration
The Neurogenic Potential of Astrocytes Is Regulated by Inflammatory Signals
Klf4 and Klf5 differentially inhibit mesoderm and endoderm differentiation in embryonic stem cells
The Long Noncoding RNA RMST Interacts with SOX2 to Regulate Neurogenesis
Long noncoding RNAs in development and disease of the central nervous system
Oct4 switches partnering from Sox2 to Sox17 to reinterpret the enhancer code and specify endoderm
Sox Transcription Factors Require Selective Interactions with Oct4 and Specific Transactivation Functions to Mediate Reprogramming
An epigenetic signature of developmental potential in neural stem cells and early neurons
Widespread binding of FUS along nascent RNA regulates alternative splicing in the brain
Neural stem cell specific fluorescent chemical probe binding to FABP7
Dysregulation of <scp>REST</scp>‐regulated coding and non‐coding <scp>RNA</scp>s in a cellular model of Huntington's disease