Area of research
Molecular Biology · Pulmonary and Respiratory Medicine
Research interest
Research focused on Primary hyperoxaluria and Oxalate, with related work in Human serum albumin, Knockout mouse, Glyoxylate cycle. Notable publications include 'An Investigational RNAi Therapeutic Targeting Glycolate Oxidase Reduces Oxalate Production in Models of Primary Hyperoxaluria', 'Crystal Structure of an HSA/FcRn Complex Reveals Recycling by Competitive Mimicry of HSA Ligands at a pH-Dependent Hydrophobic Interface', and 'Phase 1/2 Study of Lumasiran for Treatment of Primary Hyperoxaluria Type 1'.
Phase 1/2 Study of Lumasiran for Treatment of Primary Hyperoxaluria Type 1
Characterising a healthy adult with a rare HAO1 knockout to support a therapeutic strategy for primary hyperoxaluria
Reduction in urinary oxalate excretion in mouse models of Primary Hyperoxaluria by RNA interference inhibition of liver lactate dehydrogenase activity
An Investigational RNAi Therapeutic Targeting Glycolate Oxidase Reduces Oxalate Production in Models of Primary Hyperoxaluria
Crystal Structure of an HSA/FcRn Complex Reveals Recycling by Competitive Mimicry of HSA Ligands at a pH-Dependent Hydrophobic Interface