Zu-Hang Sheng

Xia Feng, Xiu-Tang Cheng, Pengli Zheng, Yan Li, Jill Hakim, Shirley Q. Zhang, Stacie M. Anderson, Kaari Linask, Ryan Prestil, Jizhong Zou, Zu-Hang Sheng , Craig Blackstone. (2023). Ligand-free mitochondria-localized mutant AR-induced cytotoxicity in spinal bulbar muscular atrophy. Brain 146, 278-294

Ning Huang and Zu-Hang Sheng. (2022). Microfluidic platforms as model systems to study CNS regeneration and axonal mitochondrial transport and energetic metabolism after injury-ischemia. Cell Regeneration  PDF

Dinesh C. Joshi, Chuan-Li Zhang, Deepali Mathur, Alex Li, Gaurav Kaushik, Zu-Hang Sheng, Shing-Yan Chiu. (2022). Tripartite crosstalk between cytokine IL-1beta, NMDA-R and misplaced mitochondrial anchor in neuronal dendrites is a novel pathway for neurodegeneration in inflammatory diseases. Journal

Joseph C. Roney, Xiu-Tang Cheng, and Zu-Hang Sheng. (2022). Neuronal endolysosomal transport and lysosomal functionality in maintaining axonostasis. Journal of Cell Biology    221, 3, 2022. PDF

Superfood for axons: Glial exosomes boost axonal energetics by delivery of SIRT2.

Neurobiology: Resetting the axon's batteries.

Kelly A. Chamberlain, Ning Huang (co-first author), Yuxiang Xie, Francesca LiCausi, Sunan Li, Yan Li, and Zu-Hang Sheng. (2021). Oligodendrocytes enhance axonal energy metabolism by deacetylation of mitochondrial proteins through transcellular delivery of SIRT2.  Neuron 109, 3456-3472. PDF

Joseph C Roney, Sunan Li, Tamar Farfel-Becker, Ning Huang, Tao Sun, Yuxiang Xie, Xiu-Tang Cheng, Mei-Yao Lin, Frances M Platt, and Zu-Hang Sheng. (2021). Lipid-mediated impairment of axonal lysosome transport contributing to autophagic stress.  Autophagy   17, 1796-1798. PDF

Qi Han, Yuxiang Xie, Josue D Ordaz, Andrew J Huh, Ning Huang, Wei Wu, Naikui Liu, Kelly A Chamberlain, Zu-Hang Sheng (lead corresponding), Xiao-Ming Xu (2020). Recovering energy deficits promotes CNS axonal regeneration and functional restoration after spinal cord injury.  Cell Metabolism 31, 623-64

Tamar Farfel-Becker, Joseph V. Roney, Xiu-Tang Cheng, Sunan Li, Sean R. Cuddy, and Zu-Hang Sheng. (2020). The secret life of degradative lysosomes in axons: delivery from the soma, enzymatic activity, and local autophagic clearance.  Autophagy   16, 167-168. PDF

Inappropriate Intrusion of an Axonal Mitochondrial Anchor into Dendrites Causes Neurodegeneration

Dinesh C Joshi, Chuan-Li Zhang, Lavanya Babujee, Jason D Vevea, Benjamin K August, Zu-Hang Sheng, Edwin R Chapman, Timothy M Gomez, Shing Yan Chiu (2019). Inappropriate Intrusion of an Axonal Mitochondrial Anchor into Dendrites Causes Neurodegeneration. Cell Reports   29, 685-696. PDF

Natalia S. Morsci, David H. Hall, Monica Driscoll, and Zu-Hang Sheng (2016). Age-related phasic patterns of mitochondrial maintenance in adult C. elegans neurons. Journal of Neuroscience , 36, 1373-1385.  PDF

Yuxiang Xie, Bing Zhou (co-first author), Mei-Yao Lin, Shiwei Wang, Kevin D. Foust, and Zu-Hang Sheng (2015). Endolysosomal Deficits Augment Mitochondria Pathology in Spinal Motor Neurons of Asymptomatic fALS Mice. Neuron 87, 355-370.  PDF

Dinesh C. Joshi, Chuan-Li Zhang, Tien-Min Lin, Anchal Gusain, Melissa G. Harris, Esther Tree, Yewin Yin, Connie Wu, Zu-Hang Sheng, Robert J Dempsey, Zsuzsanna Fabry, and Shing Yan Chiu (2015). Deletion of Mitochondrial Anchoring Protects Dysmyelinating Shiverer: Implications for Progressive MS. Jour

MUL1 acts in parallel to the PINK1/parkin pathway in regulating mitofusin and compensates for loss of PINK1/parkin

Yun J, Puri R, Yang H, Lizzio MA, Wu C, Sheng ZH, Guo M (2014). MUL1 acts in parallel to the PINK1/parkin pathway in regulating mitofusin and compensates for loss of PINK1/parkin. eLife   3, e01958. PDF

Nobuhiko Ohno, Hao Chiang, Don J Mahad, Grahame Kidd, Liping Liu, Richard M. Ransohoff, Zu-Hang Sheng, Hitoshi Komuro and Bruce D. Trapp (2014). Mitochondrial immobilization mediated by syntaphilin facilitates survival of demyelinated axons. PNAS  111, 9953-9958.  PDF

Mitochondrial transport in neurons: impact on synaptic homeostasis and neurodegeneration

Spatial Parkin Translocation and Degradation of Damaged Mitochondria via Mitophagy in Live Cortical Neurons

Long time-lapse imaging reveals unique features of PARK2/Parkin-mediated mitophagy in mature cortical neurons

Qian Cai, Hesham M Zakaria, and Zu-Hang Sheng (2012). Long time-lapse imaging reveals unique features of PARK2/Parkin-mediated mitophagy in mature cortical neurons.  Autophagy  8, 976-978.  PDF

Kim HJ, Zhong Q, Zu-Hang Sheng, Yoshimori T, Liang C, Jung JU (2012). Beclin 1-interacting autophagy protein Atg14L targets SNARE-associated protein Snapin to coordinate endocytic trafficking . Journal of Cell Science  125, 4740-4750.

Yi-Bing Zhu, Zu-Hang Sheng (2011). Increased Axonal Mitochondrial Mobility Does Not Slow ALS-like Disease in Mutant SOD1 Mice. The Journal of Biological Chemistry  286, 23432-23440. PDF

Wu LJ, Leenders AG, Cooperman S, Meyron-Holtz E, Smith S, Land W, Tsai RY, Berger UV, Sheng ZH, Rouault TA (2004). Expression of the iron transporter ferroportin in synaptic vesicles and the blood-brain barrier . Brain Res . 1001, 108-17.

Pratima Thakur, David R. Stevens, Zu-Hang Sheng and Jens Rettig (2004). Effects of PKA-mediated phosphorylation of Snapin on synaptic transmission in cultured hippocampal neurons . Journal of Neuroscience , 24, 6476-6481.

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Mitochondrial transport and energy metabolism in synaptic transmission and neuronal degeneration and regeneration

Axonal transport of endolysosomal organelles and presynaptic cargos for the maintenance of axon cellular homeostasis and presynaptic function

Mitochondrial transport and energy metabolism in synaptic transmission and neuronal degeneration and regeneration

Axonal transport of endolysosomal organelles and presynaptic cargos for the maintenance of axon cellular homeostasis and presynaptic function

Mitochondrial transport and energy metabolism in synaptic transmission and neuronal degeneration and regeneration

Axonal transport of endolysosomal organelles and presynaptic cargos for the maintenance of axon cellular homeostasis and presynaptic function

Mitochondrial transport and energy metabolism in synaptic transmission and neuronal degeneration and regeneration

Axonal transport of endolysosomal organelles and presynaptic cargos for the maintenance of axon cellular homeostasis and presynaptic function

Mitochondrial transport and energy metabolism in synaptic transmission and neuronal degeneration and regeneration

Axonal transport of endolysosomal organelles and presynaptic cargos for the maintenance of axon cellular homeostasis and presynaptic function

Mitochondrial transport and energy metabolism in synaptic transmission and nerve degeneration and regeneration

Axonal transport of endo-lysosomal organelles and presynaptic cargoes in the maintenance of axon cellular homeostasis and synaptic function

Mitochondrial transport and energy metabolism in synaptic transmission and nerve degeneration and regeneration

Axonal transport of endo-lysosomal organelles and presynaptic cargoes in the maintenance of axon cellular homeostasis and synaptic function

Mitochondrial transport: impact on synaptic transmission and neurodegeneration

Axonal transport regulates synaptic function and axonal homeostasis