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Henk M. Lokhorst

Amsterdam UMC Location VUmc · NL
Area of research
Hematology · Oncology
Research interest
Research interests include Multiple Myeloma Research and Treatments, Protein Degradation and Inhibitors, Immunotherapy and Immune Responses, and Peptidase Inhibition and Analysis.
h-index
63
citations
18,749
works
305
NIH funding
primary concept
Medicine
email

Recent publications

Bortezomib before and after high‐dose therapy in transplant‐eligible patients with newly diagnosed multiple myeloma: Long‐term overall survival after more than 10 years of follow‐up from the phase III HOVON‐65/GMMG‐HD4 trial
HemaSphere 2024cited by 2position: middledoi
Detection and localization of early- and late-stage cancers using platelet RNA
Cancer Cell 2022cited by 121position: middledoi
Lenalidomide versus bortezomib maintenance after frontline autologous stem cell transplantation for multiple myeloma
Blood Cancer Journal 2021cited by 33position: middledoi
Bortezomib-Based Induction and Maintenance Overcomes the Negative Prognostic Impact of Renal Impairment and del17p in Transplant-Eligible Myeloma Patients: Long Term Results from the Phase III HOVON-65/GMMG-HD4 Study after Median 137 Months Follow up
Blood 2019cited by 3position: middledoi
Comparison of bortezomib versus lenalidomide maintenance therapy in newly-diagnosed, transplant-eligible multiple myeloma: Results from the phase III GMMG-HD4 and -MM5 trials
Clinical Lymphoma Myeloma & Leukemia 2019cited by 1position: middledoi
High‐Parameter Mass Cytometry Evaluation of Relapsed/Refractory Multiple Myeloma Patients Treated with Daratumumab Demonstrates Immune Modulation as a Novel Mechanism of Action
Cytometry Part A 2018cited by 159position: middledoi
Impact of Fc gamma receptor polymorphisms on efficacy and safety of daratumumab in relapsed/refractory multiple myeloma
British Journal of Haematology 2018cited by 23position: middledoi
Treatment Response and Long-Term Survival in Multiple Myeloma in the GMMG-HD4 Trial - Neither Profit All Molecular Entities Alike, Nor Are Remissions to Different Regimen Equal
Blood 2018cited by 0position: middledoi
Effects of daratumumab on natural killer cells and impact on clinical outcomes in relapsed or refractory multiple myeloma
Blood Advances 2017cited by 222position: middledoi
Subcutaneous Delivery of Daratumumab in Patients (pts) with Relapsed or Refractory Multiple Myeloma (RRMM): Pavo, an Open-Label, Multicenter, Dose Escalation Phase 1b Study
Blood 2017cited by 27position: middledoi
Daratumumab depletes CD38+ immune regulatory cells, promotes T-cell expansion, and skews T-cell repertoire in multiple myeloma
Blood 2016cited by 908position: middledoi
Clinical efficacy of daratumumab monotherapy in patients with heavily pretreated relapsed or refractory multiple myeloma
Blood 2016cited by 404position: middledoi
Pharmacokinetics of Daratumumab Following Intravenous Infusion in Relapsed or Refractory Multiple Myeloma After Prior Proteasome Inhibitor and Immunomodulatory Drug Treatment
Clinical Pharmacokinetics 2016cited by 82position: middledoi
Practical Considerations for the Use of Daratumumab, a Novel CD38 Monoclonal Antibody, in Myeloma
Drugs 2016cited by 46position: middledoi
Open-Label, Multicenter, Dose Escalation Phase 1b Study to Assess the Subcutaneous Delivery of Daratumumab in Patients (pts) with Relapsed or Refractory Multiple Myeloma (PAVO)
Blood 2016cited by 27position: middledoi
Outcome of allogeneic transplantation in newly diagnosed and relapsed/refractory multiple myeloma: long‐term follow‐up in a single institution
European Journal Of Haematology 2016cited by 19position: middledoi
Targeting CD38 with Daratumumab Monotherapy in Multiple Myeloma
New England Journal of Medicine 2015cited by 1,112position: firstdoi
American Society of Blood and Marrow Transplantation, European Society of Blood and Marrow Transplantation, Blood and Marrow Transplant Clinical Trials Network, and International Myeloma Working Group Consensus Conference on Salvage Hematopoietic Cell Transplantation in Patients with Relapsed Multiple Myeloma
Biology of Blood and Marrow Transplantation 2015cited by 162position: middledoi
Clinical Efficacy of Daratumumab Monotherapy in Patients with Heavily Pretreated Relapsed or Refractory Multiple Myeloma
Blood 2015cited by 29position: middledoi
Preclinical Evidence for the Therapeutic Potential of CD38-Targeted Immuno-Chemotherapy in Multiple Myeloma Patients Refractory to Lenalidomide and Bortezomib
Clinical Cancer Research 2014cited by 149position: middledoi
IMWG consensus on maintenance therapy in multiple myeloma
Blood 2012cited by 194position: middledoi
Daratumumab, a CD38 Monoclonal Antibody in Patients with Multiple Myeloma - Data From a Dose-Escalation Phase I/II Study
Blood 2012cited by 70position: middledoi

Grants

No grants ingested yet.

Frequent collaborators

Torben Plesner · University of Southern Denmark9 papers (2012–2018)Niels W.C.J. van de Donk · National Cancer Center8 papers (2014–2018)A. Kate Sasser · Tempus Labs (United States)7 papers (2015–2018)Hareth Nahi · Karolinska Institutet7 papers (2012–2017)Tahamtan Ahmadi · Genmab (United States)7 papers (2015–2017)Saad Z. Usmani · Weill Cornell Medicine6 papers (2015–2018)Sagar Lonial · Emory University6 papers (2015–2018)Paul G. Richardson · Harvard University5 papers (2012–2018)Tuna Mutis · Utrecht University5 papers (2014–2018) · 5 papers (2015–2017)Tineke Casneuf · Genmab (United States)4 papers (2016–2018) · 4 papers (2016–2017)Inger S. Nijhof · St. Antonius Ziekenhuis4 papers (2014–2018)Pieter Sonneveld · Erasmus MC3 papers (2016–2024)Ajai Chari · UCSF Helen Diller Family Comprehensive Cancer Center3 papers (2016–2017)Brendan M. Weiss · McDermott International (United States)3 papers (2015–2016) · 3 papers (2015–2018)Jesús F. San Miguel · Centro de Investigación Biomédica en Red de Cáncer3 papers (2016–2017)María‐Victoria Mateos · Spanish Society of Hematology and Hemotherapy3 papers (2016–2017)Christopher Chiu · The University of Sydney3 papers (2017–2018)