Area of research
Epidemiology · Microbiology
Research interest
Research focused on Streptococcus pneumoniae and Microbiology, with related work in Nasal administration, Nanogel, Immunology. Notable publications include 'Nanogel-Based PspA Intranasal Vaccine Prevents Invasive Disease and Nasal Colonization by Streptococcus pneumoniae', 'Nontypeable Pneumococci Can Be Divided into Multiple cps Types, Including One Type Expressing the Novel Gene pspK', and 'Nanogel-based pneumococcal surface protein A nasal vaccine induces microRNA-associated Th17 cell responses with neutralizing antibodies against Streptococcus pneumoniae in macaques'.
Liver macrophages and sinusoidal endothelial cells execute vaccine-elicited capture of invasive bacteria
PspA-mediated aggregation protects <i>Streptococcus pneumoniae</i> against desiccation on fomites
A Jack of All Trades: The Role of Pneumococcal Surface Protein A in the Pathogenesis of Streptococcus pneumoniae
A nanogel-based trivalent PspA nasal vaccine protects macaques from intratracheal challenge with pneumococci
Streptococcus pneumoniae binds to host GAPDH on dying lung epithelial cells worsening secondary infection following influenza
Streptococcus pneumoniae Binds to Host Lactate Dehydrogenase via PspA and PspC To Enhance Virulence
Characterization and Specification of a Trivalent Protein-Based Pneumococcal Vaccine Formulation Using an Adjuvant-Free Nanogel Nasal Delivery System
A Phase 1 Randomized, Placebo-controlled, Observer-blinded Trial to Evaluate the Safety and Immunogenicity of Inactivated Streptococcus pneumoniae Whole-cell Vaccine in Adults
New Strategy Is Needed to Prevent Pneumococcal Meningitis
PspA facilitates evasion of pneumococci from bactericidal activity of neutrophil extracellular traps (NETs)
The diversity of the proline-rich domain of pneumococcal surface protein A (PspA): Potential relevance to a broad-spectrum vaccine
Novel Immunoprotective Proteins of Streptococcus pneumoniae Identified by Opsonophagocytosis Killing Screen
Macrophage Rac2 Is Required to Reduce the Severity of Cigarette Smoke–induced Pneumonia
Dendritic cell‐targeting DNA‐based nasal adjuvants for protective mucosal immunity to <i>Streptococcus pneumoniae</i>
Transcutaneous immunization with pneumococcal surface protein A in mice
Neutrophil Extracellular Traps and Fibrin in Otitis Media
Pneumolysin plays a key role at the initial step of establishing pneumococcal nasal colonization
Free Sialic Acid Acts as a Signal That Promotes Streptococcus pneumoniae Invasion of Nasal Tissue and Nonhematogenous Invasion of the Central Nervous System
Pneumococcal pep27 mutant immunization stimulates cytokine secretion and confers long-term immunity with a wide range of protection, including against non-typeable strains
Nanogel-based pneumococcal surface protein A nasal vaccine induces microRNA-associated Th17 cell responses with neutralizing antibodies against Streptococcus pneumoniae in macaques
<i>Streptococcus pneumoniae</i> induces pyroptosis through the regulation of autophagy in murine microglia
Multivalent Pneumococcal Protein Vaccines Comprising Pneumolysoid with Epitopes/Fragments of CbpA and/or PspA Elicit Strong and Broad Protection
ClpL is a chaperone without auxiliary factors
Ethanol-Induced Alcohol Dehydrogenase E (AdhE) Potentiates Pneumolysin in Streptococcus pneumoniae
Protective properties of a fusion pneumococcal surface protein A (PspA) vaccine against pneumococcal challenge by five different PspA clades in mice
Mapping of Epitopes Recognized by Antibodies Induced by Immunization of Mice with PspA and PspC
Pneumococcal PspA and PspC proteins: Potential vaccine candidates for experimental otitis media
Nanogel-Based PspA Intranasal Vaccine Prevents Invasive Disease and Nasal Colonization by Streptococcus pneumoniae
Current status and perspectives on protein-based pneumococcal vaccines