Area of research
Genetics · Pulmonary and Respiratory Medicine
Research interest
Research topics from publications: Renal-targeted delivery of triptolide by entrapment in pegylated TRX-20-modified liposomes; Multiple‐Coated PLGA Nanoparticles Loading Triptolide Attenuate Injury of a Cellular Model of Alzheimer’s Disease. Representative work: Abstract: Previously, 3,5-dipentadecyloxybenzamidine hydrochloride (TRX-20)-modified liposomes were reported to specifically target mesangial cells (MCs) in glomeruli. To further gain a better understanding of the characteristics and potential application for glomerular diseases of TRX-20-modified liposomes, we synthesized TRX-20 and prepared TRX-20-modified liposomes (TRX-LPs) with different molar ratios – 6% (6%-TRX-LP), 11% (11%-TRX-LP), and 14% (14%-TRX-LP) – of TRX-20 to total lipid in the present study. All TRX-LPs exhibited concentration-dependent toxicity against the MCs at a lipid concentration ranging from 0.01 to 1.0 mg/mL with IC 50 values of 3.45, 1.13, and 0.55 mg/mL, respectiv Alzheimer’s disease (AD) is the most common neurodegenerative disease, which is associated with extracellular deposition of amyloid‐ β proteins (A β ). It has been reported that triptolide (TP), an immunosuppressive and anti‐inflammatory agent extracted from a Chinese herb Tripterygium wilfordii , shows potential neuroprotective effects pertinent to AD. However, the clinical use of TP for AD could be hampered due to its high toxicity, instability, poor water solubility, and nonspecific biodistribution after administration. In this paper, we reported a kind of multiple‐coated PLGA nanoparticle with the entrapment of TP and surface coated by chitosan hydrochloride, Tween‐80, PEG20000, and born