Area of research
Cardiology and Cardiovascular Medicine · Molecular Biology
Research interest
Research interests include Cardiac electrophysiology and arrhythmias, Ion channel regulation and function, Neuroscience and Neural Engineering, and Neuroscience and Neuropharmacology Research.
Propofol rescues voltage-dependent gating of HCN1 channel epilepsy mutants
Similar voltage-sensor movement in spHCN channels can cause closing, opening, or inactivation
A second S4 movement opens hyperpolarization-activated HCN channels
A general mechanism of KCNE1 modulation of KCNQ1 channels involving non-canonical VSD-PD coupling
Gating mechanism of hyperpolarization-activated HCN pacemaker channels
Polyunsaturated fatty acid analogues differentially affect cardiac NaV, CaV, and KV channels through unique mechanisms
Polyunsaturated fatty acids produce a range of activators for heterogeneous IKs channel dysfunction
ω‐6 and ω‐9 polyunsaturated fatty acids with double bonds near the carboxyl head have the highest affinity and largest effects on the cardiac <scp><i>I</i><sub>K</sub></scp><sub>s</sub> potassium channel
KCNE1 and KCNE3 modulate KCNQ1 channels by affecting different gating transitions
Molecular mechanism of Zn<sup>2+</sup>inhibition of a voltage-gated proton channel
KCNE3 acts by promoting voltage sensor activation in KCNQ1
KCNE1 divides the voltage sensor movement in KCNQ1/KCNE1 channels into two steps
Molecular mechanism of voltage sensing in voltage-gated proton channels