Area of research
Physiology · Cellular and Molecular Neuroscience
Research interest
Research topics from publications: Liver-heart crosstalk controls IL-22 activity in cardiac protection after myocardial infarction; Dual Role of α-MSH in Colitis Progression: Mediating Neutrophil Differentiation via Bone Marrow. Representative work: Supplementation of IL-22 in the first week after acute MI effectively prevented left ventricular dysfunction and heart failure. This activity of IL-22 involved crosstalk between the liver and heart after demonstrating a role of the hepatic STAT3-FGF21 axis in IL-22-induced post-MI cardiac protection Background: Inflammatory bowel disease (IBD) comprises a group of autoimmune disorders characterized by chronicity and resistance to cure, with an unknown etiology. Recent studies on the brain-gut axis suggest that the central nervous system (CNS), particularly the hypothalamic-pituitary axis (HPA), may play a crucial role in modulating the immune system and influencing disease progression. However, the specific role and mechanism of the HPA in IBD pathogenesis remain unclear. This study aims to investigate the alterations in the HPA and its potential roles during IBD development. Methods: We utilized a dextran sodium sulfate (DSS)-induced colitis model in mice and employed immunofluorescenc