Area of research
Microbiology · Molecular Medicine
Research interest
Research topics from publications: Fish-derived cationic antimicrobial peptide piscidin 1 exerts broad-spectrum bactericidal activities against multidrug-resistant Gram-negative pathogens. Representative work: The emergence and swift dissemination of multidrug-resistant (MDR) bacteria have posed a grave threat to public health. To counteract the escalating menace posed by MDR organisms, particularly mcr-1 , bla NDM-1 , or/and tet (X3/X4)-positive Gram-negative pathogens, the identification of novel antimicrobial agents or treatment strategies is imperative. Antimicrobial peptides (AMPs) have emerged as potential antibiotic candidates. In this study, we discovered that piscidin 1, a cationic AMP derived from fish, exhibits potent antibacterial activity against MDR bacteria. Safety and stability assessments revealed that this peptide demonstrates robust resistance to various physiological conditions