Jisheng Nie

Area of research

Molecular Biology · Electrical and Electronic Engineering

Research interest

Research topics from publications: Two-Dimensional Nanozyme Based on Iron Metal–Organic Gel/Carboxylated Graphene Oxide for Electrochemical and Colorimetric Dual-Mode Detection of Hydrogen Peroxide; A golgi targeting viscosity rotor for cancer diagnosis in living cells and tissues; Size-Dependent Cytotoxicity and Multi-Omic Changes Induced by Amorphous Silicon Nanoparticles in HepG2 Cells; Autogenous-reduction-engineered MOF/GO hybrids as a universal ternary nanocomposite platform for simultaneous electrochemical sensing of uric acid, dopamine and ascorbic acid. Representative work: Metal–organic gel (MOG) is a distinctive metal–organic hybrid material with a unique porous structure and exceptional catalytic site accessibility. The rational design of an electrochemical and colorimetric dual-mode sensor platform utilizing the peroxidase (POD)-like activity of MOG for the detection of H2O2 is crucial for clinical diagnosis. In this article, a two-dimensional composite nanozyme based on Fe-MOG and carboxylated graphene oxide (GO-COOH) was synthesized, which serves dual functions to establish electrochemical sensing and colorimetric sensing based on its excellent electrocatalytic reduction of H2O2 and POD-like activity. GO-COOH played a critical role, and the electrochemica (1) Background: Silica nanoparticles (SiO2 NPs) have a high potential for human exposure and tend to accumulate in the liver. This study aimed to explore the size-dependent cytotoxicity induced by SiO2 NPs and identify key molecular pathways at the in vitro level through proteomics, metabolomics, and a combination of multiple omics methods. (2) Methods: The human hepatoma cells (HepG2) cells were exposed to SiO2 NPs of three different sizes (60, 250, and 400 nm) at doses of 0, 12.5, 25, 50, 100, and 200 μg/mL for 24 h. (3) Results: Exposure to 60 nm SiO2 NPs induced more reduction in cell viability than the other two larger-scale particles. Changes in the metabolomic and proteomic profiles o

Looking for a research collaborator?

Search millions of scientists by field, institution, impact, and funding status — see their work, find their email, and reach out directly.