Susu Guo

Area of research

Pulmonary and Respiratory Medicine · Molecular Biology

Research interest

Research topics from publications: Carbon dots as a novel photosensitizer for photodynamic therapy of cancer and bacterial infectious diseases: recent advances; A review of carbon nanomaterials/bacterial cellulose composites for nanomedicine applications; Mussel-inspired immunomodulatory and osteoinductive dual-functional hydroxyapatite nanoplatform for promoting bone regeneration; Copper doped carbon dots modified bacterial cellulose with enhanced antibacterial and immune regulatory functions for accelerating wound healing; Applications of Bacterial Cellulose-Based Composite Materials in Hard Tissue Regenerative Medicine; Carbon dots-cisplatin nano drug delivery system induces the death of oral tongue squamous cell under self-targeting chemical/photodynamic combined therapy; Synthesis of Eucommia ulmoides-derived carbon dots for anti-inflammatory and accelerated wound healing; Synthesis, applications in therapeutics, and bioimaging of traditional Chinese medicine-derived carbon dots. Representative work: Carbon dots (CDs) are novel carbon-based nanomaterials that have been used as photosensitizer-mediated photodynamic therapy (PDT) in recent years due to their good photosensitizing activity. Photosensitizers (PSs) are main components of PDT that can produce large amounts of reactive oxygen species (ROS) when stimulated by light source, which have the advantages of low drug resistance and high therapeutic efficiency. CDs can generate ROS efficiently under irradiation and therefore have been extensively studied in disease local phototherapy. In tumor therapy, CDs can be used as PSs or PS carriers to participate in PDT and play an extremely important role. In bacterial infectious diseases, CDs Abstract Simultaneously modulating the inflammatory microenvironment and promoting local bone regeneration is one of the main challenges in treating bone defects. In recent years, osteoimmunology has revealed that the immune system plays an essential regulatory role in bone regeneration and that macrophages are critical components. In this work, a mussel-inspired immunomodulatory and osteoinductive dual-functional hydroxyapatite nano platform (Gold/hydroxyapatite nanocomposites functionalized with polydopamine - PDA@Au-HA) is developed to accelerate bone tissues regeneration by regulating the immune microenvironment. PDA coating endows nanomaterials with the ability to

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