Area of research
Molecular Biology · Cancer Research
Research interest
Research interests include Mitochondrion, Bioenergetics, Biology, Oxidative phosphorylation, Cell biology, and Oxidative stress.
The interplay between sex, time of day, fasting status, and their impact on cardiac mitochondrial structure, function, and dynamics
Acute inhibition of OGA sex-dependently alters the networks associated with bioenergetics, autophagy, and neurodegeneration
Fasting drives the metabolic, molecular and geroprotective effects of a calorie-restricted diet in mice
Metabolic derangement in polycystic kidney disease mouse models is ameliorated by mitochondrial-targeted antioxidants
New Insights Into the Biology of Protein O-GlcNAcylation: Approaches and Observations
Defining the Dynamic Regulation of O-GlcNAc Proteome in the Mouse Cortex---the O-GlcNAcylation of Synaptic and Trafficking Proteins Related to Neurodegenerative Diseases
ZKSCAN3 in severe bacterial lung infection and sepsis-induced immunosuppression
Dynamic Imaging of LDH Inhibition in Tumors Reveals Rapid In Vivo Metabolic Rewiring and Vulnerability to Combination Therapy
Pyrazole-Based Lactate Dehydrogenase Inhibitors with Optimized Cell Activity and Pharmacokinetic Properties
Targeting Glycolysis through Inhibition of Lactate Dehydrogenase Impairs Tumor Growth in Preclinical Models of Ewing Sarcoma
Mitochondria in precision medicine; linking bioenergetics and metabolomics in platelets
Acute increases in <i>O</i>-GlcNAc indirectly impair mitochondrial bioenergetics through dysregulation of LonP1-mediated mitochondrial protein complex turnover
A precision medicine approach to defining the impact of doxorubicin on the bioenergetic-metabolite interactome in human platelets
Integrative metabolomics and transcriptomics signatures of clinical tolerance to Plasmodium vivax reveal activation of innate cell immunity and T cell signaling
Methods for assessing mitochondrial quality control mechanisms and cellular consequences in cell culture
Regulation of autophagy, mitochondrial dynamics, and cellular bioenergetics by 4-hydroxynonenal in primary neurons
Inhibition of autophagy with bafilomycin and chloroquine decreases mitochondrial quality and bioenergetic function in primary neurons
Pleiotropic effects of 4-hydroxynonenal on oxidative burst and phagocytosis in neutrophils
Metabolic Plasticity in Resting and Thrombin Activated Platelets
Cardiomyocyte mitochondrial oxidative stress and cytoskeletal breakdown in the heart with a primary volume overload
Upregulation of autophagy decreases chlorine-induced mitochondrial injury and lung inflammation
Defining the effects of storage on platelet bioenergetics: The role of increased proton leak
Modification of platelet proteins by 4-hydroxynonenal: Potential Mechanisms for inhibition of aggregation and metabolism
A review of the mitochondrial and glycolytic metabolism in human platelets and leukocytes: Implications for their use as bioenergetic biomarkers
Bioenergetics and the Oxidative Burst: Protocols for the Isolation and Evaluation of Human Leukocytes and Platelets
Hemoglobin-associated oxidative stress in the pericardial compartment of postoperative cardiac surgery patients
Methods for defining distinct bioenergetic profiles in platelets, lymphocytes, monocytes, and neutrophils, and the oxidative burst from human blood
Mitochondrial genetic background modulates bioenergetics and susceptibility to acute cardiac volume overload
Mitochondria-targeted heme oxygenase-1 decreases oxidative stress in renal epithelial cells
Inhibition of glycolysis attenuates 4-hydroxynonenal-dependent autophagy and exacerbates apoptosis in differentiated SH-SY5Y neuroblastoma cells