Area of research
Cancer Research · Molecular Biology
Research interest
Research interests include Cancer Genomics and Diagnostics, HER2/EGFR in Cancer Research, CRISPR and Genetic Engineering, and Monoclonal and Polyclonal Antibodies Research.
A functional genomic approach to actionable gene fusions for precision oncology
POT1 Regulates Proliferation and Confers Sexual Dimorphism in Glioma
PIK3CA variants selectively initiate brain hyperactivity during gliomagenesis
The RNA-binding protein AKAP8 suppresses tumor metastasis by antagonizing EMT-associated alternative splicing
PI4KIIIβ is a therapeutic target in chromosome 1q–amplified lung adenocarcinoma
Systematic Functional Annotation of Somatic Mutations in Cancer
A-to-I RNA Editing Contributes to Proteomic Diversity in Cancer
RNA editing derived epitopes function as cancer antigens to elicit immune responses
TMEM106B drives lung cancer metastasis by inducing TFEB-dependent lysosome synthesis and secretion of cathepsins
Combinatorial inhibition of PTPN12-regulated receptors leads to a broadly effective therapeutic strategy in triple-negative breast cancer
In vivo screening identifies GATAD2B as a metastasis driver in KRAS-driven lung cancer
A Pan-Cancer Proteogenomic Atlas of PI3K/AKT/mTOR Pathway Alterations
Rational combination therapy with PARP and MEK inhibitors capitalizes on therapeutic liabilities in <i>RAS</i> mutant cancers
HER2 Reactivation through Acquisition of the HER2 L755S Mutation as a Mechanism of Acquired Resistance to HER2-targeted Therapy in HER2+ Breast Cancer
The Genomic Landscape and Clinical Relevance of A-to-I RNA Editing in Human Cancers
Lysyl hydroxylase 2 induces a collagen cross-link switch in tumor stroma
Identification of Variant-Specific Functions of <i>PIK3CA</i> by Rapid Phenotyping of Rare Mutations
The GABA Transaminase, ABAT, Is Essential for Mitochondrial Nucleoside Metabolism
Mutations in FBXL4 Cause Mitochondrial Encephalopathy and a Disorder of Mitochondrial DNA Maintenance