Area of research
Physiology · Molecular Biology
Research interest
Research interests include Alzheimer's disease research and treatments, Protein Structure and Dynamics, Enzyme Structure and Function, and Mitochondrial Function and Pathology.
Structural basis for the mechanisms of human presequence protease conformational switch and substrate recognition
Degradation of Alzheimer’s Amyloid-β by a Catalytically Inactive Insulin-Degrading Enzyme
Pseudomonas aeruginosa exoenzyme Y directly bundles actin filaments
Structural analysis of Mycobacterium tuberculosis M13 metalloprotease Zmp1 open states
Identification of ebselen as a potent inhibitor of insulin degrading enzyme by a drug repurposing screening
Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme
Locking the Elbow: Improved Antibody Fab Fragments as Chaperones for Structure Determination
ACF7 regulates inflammatory colitis and intestinal wound response by orchestrating tight junction dynamics
Structural basis for oligomerization and glycosaminoglycan binding of CCL5 and CCL3
In vivo epidermal migration requires focal adhesion targeting of ACF7
Catalytic site inhibition of insulin-degrading enzyme by a small molecule induces glucose intolerance in mice
Molecular Basis of Substrate Recognition and Degradation by Human Presequence Protease
Conformational states and recognition of amyloidogenic peptides of human insulin-degrading enzyme