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Manuel Ruíz Borrego

Universidad de Sevilla ·
Area of research
Oncology · Pulmonary and Respiratory Medicine
Research interest
Research interests include Advanced Breast Cancer Therapies, HER2/EGFR in Cancer Research, Breast Cancer Treatment Studies, and Cancer Treatment and Pharmacology.
h-index
33
citations
5,934
works
179
NIH funding
primary concept
Medicine
email

Recent publications

Patient-reported outcomes in the SERENA-6 trial of camizestrant plus CDK4/6 inhibitor in patients with advanced breast cancer and emergent ESR1 mutations during first-line endocrine-based therapy
Annals of Oncology 2025cited by 4position: middledoi
Imlunestrant with or without Abemaciclib in Advanced Breast Cancer
New England Journal of Medicine 2024cited by 141position: middledoi
A phase III trial of adjuvant ribociclib plus endocrine therapy versus endocrine therapy alone in patients with HR-positive/HER2-negative early breast cancer: final invasive disease-free survival results from the NATALEE trial
Annals of Oncology 2024cited by 85position: middledoi
A phase I dose escalation and expansion trial of the next-generation oral SERD camizestrant in women with ER-positive, HER2-negative advanced breast cancer: SERENA-1 monotherapy results
Annals of Oncology 2024cited by 58position: middledoi
Alpelisib plus fulvestrant in PIK3CA-mutated, hormone receptor-positive advanced breast cancer after a CDK4/6 inhibitor (BYLieve): one cohort of a phase 2, multicentre, open-label, non-comparative study
The Lancet Oncology 2024cited by 33position: middledoi
Impact of coadministration of proton-pump inhibitors and palbociclib in hormone receptor-positive/HER2-negative advanced breast cancer
The Breast 2024cited by 5position: middledoi
Interrupting Endocrine Therapy to Attempt Pregnancy after Breast Cancer
New England Journal of Medicine 2023cited by 211position: middledoi
Abstract P3-07-28: SERENA-1: Updated analyses from a Phase 1 study of the next generation oral selective estrogen receptor degrader camizestrant (AZD9833) combined with abemaciclib, in women with ER-positive, HER2-negative advanced breast cancer
Cancer Research 2023cited by 14position: middledoi
Abstract PD13-10: PD13-10 Impact of Proton Pump Inhibitors (PPI) on Palbociclib (PAL) Outcomes in Hormone Receptor-Positive, HER2-Negative Advanced Breast Cancer (HR+/HER2- ABC): Exploratory Analysis of the PARSIFAL Trial
Cancer Research 2023cited by 5position: middledoi
Serena-1: Updated analyses from a phase 1 study (parts C/D) of the next-generation oral SERD camizestrant (AZD9833) in combination with palbociclib, in women with ER-positive, HER2-negative advanced breast cancer.
Journal of Clinical Oncology 2022cited by 41position: middledoi
Treatment With Etirinotecan Pegol for Patients With Metastatic Breast Cancer and Brain Metastases
JAMA Oncology 2022cited by 23position: middledoi
Palbociclib with Fulvestrant or Letrozole in Endocrine-Sensitive Patients with HR-Positive/HER2-Negative Advanced Breast Cancer: A Detailed Safety Analysis of the Randomized PARSIFAL Trial
The Oncologist 2022cited by 20position: middledoi
Alpelisib plus fulvestrant in PIK3CA-mutated, hormone receptor-positive advanced breast cancer after a CDK4/6 inhibitor (BYLieve): one cohort of a phase 2, multicentre, open-label, non-comparative study
The Lancet Oncology 2021cited by 346position: middledoi
Palbociclib with adjuvant endocrine therapy in early breast cancer (PALLAS): interim analysis of a multicentre, open-label, randomised, phase 3 study
The Lancet Oncology 2021cited by 254position: middledoi
Fulvestrant-Palbociclib vs Letrozole-Palbociclib as Initial Therapy for Endocrine-Sensitive, Hormone Receptor–Positive, <i>ERBB2</i>-Negative Advanced Breast Cancer
JAMA Oncology 2021cited by 104position: middledoi
Abstract GS3-00: First results from a phase III randomized clinical trial of standard adjuvant endocrine therapy (ET) +/- chemotherapy (CT) in patients (pts) with 1-3 positive nodes, hormone receptor-positive (HR+) and HER2-negative (HER2-) breast cancer (BC) with recurrence score (RS) &amp;lt; 25: SWOG S1007 (RxPonder)
Cancer Research 2021cited by 88position: middledoi
Who are the women who enrolled in the POSITIVE trial: A global study to support young hormone receptor positive breast cancer survivors desiring pregnancy
The Breast 2021cited by 54position: middledoi
Abstract PS11-05: Updated data from SERENA-1: A Phase 1 dose escalation and expansion study of the next generation oral SERD AZD9833 as a monotherapy and in combination with palbociclib, in women with ER-positive, HER2-negative advanced breast cancer
Cancer Research 2021cited by 32position: middledoi
Abstract PS10-17: Palbociclib (P) in combination with fulvestrant (F) or letrozole (L) in endocrine-sensitive patients (pts) with hormone receptor (HR)[+]/HER2[-] metastatic breast cancer (MBC): detailed safety analysis from a multicenter, randomized, open-label, phase II trial (PARSIFAL)
Cancer Research 2021cited by 0position: middledoi
Final Efficacy Results of Neratinib in HER2-positive Hormone Receptor-positive Early-stage Breast Cancer From the Phase III ExteNET Trial
Clinical Breast Cancer 2020cited by 213position: middledoi
Improved tolerability of neratinib in patients with HER2-positive early-stage breast cancer: the CONTROL trial
Annals of Oncology 2020cited by 105position: middledoi
EDIL3 promotes epithelial–mesenchymal transition and paclitaxel resistance through its interaction with integrin αVβ3 in cancer cells
Cell Death Discovery 2020cited by 61position: middledoi
Alpelisib (ALP) + fulvestrant (FUL) in patients (pts) with <i>PIK3CA-</i>mutated (mut) hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2–) advanced breast cancer (ABC) previously treated with cyclin-dependent kinase 4/6 inhibitor (CDKi) + aromatase inhibitor (AI): BYLieve study results.
Journal of Clinical Oncology 2020cited by 56position: middledoi
Neratinib after trastuzumab-based adjuvant therapy in HER2-positive breast cancer (ExteNET): 5-year analysis of a randomised, double-blind, placebo-controlled, phase 3 trial
The Lancet Oncology 2017cited by 587position: middledoi
Fulvestrant 500 mg versus anastrozole 1 mg for hormone receptor-positive advanced breast cancer (FALCON): an international, randomised, double-blind, phase 3 trial
The Lancet 2016cited by 599position: middledoi
Defining Breast Cancer Intrinsic Subtypes by Quantitative Receptor Expression
The Oncologist 2015cited by 198position: middledoi
PAM50 proliferation score as a predictor of weekly paclitaxel benefit in breast cancer
Breast Cancer Research and Treatment 2013cited by 102position: middledoi
Obesity and survival in operable breast cancer patients treated with adjuvant anthracyclines and taxanes according to pathological subtypes: a pooled analysis
Breast Cancer Research 2013cited by 101position: middledoi
PAM50 Breast Cancer Subtyping by RT-qPCR and Concordance with Standard Clinical Molecular Markers
BMC Medical Genomics 2012cited by 342position: middledoi

Grants

No grants ingested yet.

Frequent collaborators

Nicholas C. Turner · Queensland University of Technology6 papers (2020–2025) · 5 papers (2013–2024)Serena Di Cosimo · Fondazione IRCCS Istituto Nazionale dei Tumori4 papers (2021–2024)Frederik Marmé · Hospital Universitario Virgen del Rocío4 papers (2021–2024)Elena Aguirre · UPMC Hillman Cancer Center4 papers (2021–2024)Antonio Llombart‐Cussac · MedSIR (Spain)4 papers (2021–2024)Duncan Wheatley · Royal Cornwall Hospital Trust4 papers (2021–2024)Javier Cortés · Universidade Nova de Lisboa4 papers (2021–2024)Florence Dalenc · Inserm4 papers (2021–2024)Joseph Gligorov · Unité de recherche sur les maladies cardiovasculaires et métaboliques4 papers (2021–2024)Kepa Amillano · Hospital Universitari Sant Joan de Reus4 papers (2021–2024)Stephen Chia · BC Cancer Agency4 papers (2015–2024)Miguel Sampayo-Cordero · Medica (United States)4 papers (2021–2024)Andreas Schneeweiß · NSABP Foundation4 papers (2021–2024)Aleix Prat · Clínica Girona4 papers (2015–2024)José Manuel Pérez-García · Asociación Española Contra el Cáncer4 papers (2021–2024) · 4 papers (2021–2024)Florence Lerebours · Institut Curie3 papers (2020–2024)Patrick Neven · European Organisation for Research and Treatment of Cancer3 papers (2020–2024)Juan Pablo Zarate · Novartis (United States)3 papers (2020–2024)