Area of research
Immunology · Oncology
Research interest
Research interests include interferon and immune responses, Cytokine Signaling Pathways and Interactions, Immune Response and Inflammation, and SARS-CoV-2 and COVID-19 Research.
Emerging role of immunogenic cell death in cancer immunotherapy
Expansion of interferon inducible gene pool via USP18 inhibition promotes cancer cell pyroptosis
Reprogramming of tumor-associated macrophages via NEDD4-mediated CSF1R degradation by targeting USP18
Type I Interferon Regulates a Coordinated Gene Network to Enhance Cytotoxic T Cell–Mediated Tumor Killing
Negative regulation of type I IFN signaling
STAT2 is an essential adaptor in USP18-mediated suppression of type I interferon signaling
Type I IFN induces protein ISGylation to enhance cytokine expression and augments colonic inflammation
Usp18 deficient mammary epithelial cells create an antitumour environment driven by hypersensitivity to IFN‐λ and elevated secretion of Cxcl10