Area of research
Pathology and Forensic Medicine · Molecular Biology
Research interest
Research interests include Cancer Mechanisms and Therapy, Acute Myeloid Leukemia Research, Protein Kinase Regulation and GTPase Signaling, and Phagocytosis and Immune Regulation.
Loss of a 7q gene,<i>CUX1</i>, disrupts epigenetically driven DNA repair and drives therapy-related myeloid neoplasms
Gene dosage effect of CUX1 in a murine model disrupts HSC homeostasis and controls the severity and mortality of MDS
Targeting the PIM protein kinases for the treatment of a T-cell acute lymphoblastic leukemia subset
The haploinsufficient tumor suppressor, CUX1, acts as an analog transcriptional regulator that controls target genes through distal enhancers that loop to target promoters
Pim1 kinase regulates c-Kit gene translation
Activation of Pim Kinases Is Sufficient to Promote Resistance to MET Small-Molecule Inhibitors