Area of research
Health · Pharmaceutical Science
Research interest
Research topics from publications: A study on the preparation conditions of lidocaine microemulsion based on multi-objective genetic algorithm. Representative work: Background: Topical lidocaine microemulsion preparations with low toxicity, low irritation, strong transdermal capability and convenient administration are urgently needed. Methods: Box-Behnken design was performed for three preparation conditions of 5% lidocaine microemulsions: mass ratio of the mass ratio of surfactant/(oil phase + surfactant) (X 1 ), the mass ratio of olive oil/(α-linolenic acid + linoleic acid) (X 2 ) and the water content W% (X 3 ). Then, five multi-objective genetic algorithms were used to optimize the three evaluation indices to optimize the effects of lidocaine microemulsion preparations. Finally, the ideal optimization scheme was experimentally verified. Results: No