Area of research
Cancer Research · Molecular Biology
Research interest
Research topics from publications: Multi-omics reveals immune response and metabolic profiles during high-altitude mountaineering; Cell-free DNA as a potential alternative to genomic DNA in genetic studies. Representative work: natural killer cells. In contrast, during extreme-altitude mountaineering, the activation of inflammatory responses and impairment of immune effector function are observed, concomitant with an increased cellular response to hypoxia and oxidative stress pathways. Furthermore, glycolysis and antioxidant gene expression are upregulated during extreme-altitude mountaineering. Plasma metabolic analysis reveals significant alterations, involving enhanced glutamine and fatty acid metabolism Next-generation sequencing has greatly advanced genomics, enabling large-scale studies of population genetics and complex traits. Genomic DNA (gDNA) from white blood cells has traditionally been the main data source, but cell-free DNA (cfDNA), found in bodily fluids as fragmented DNA, is increasingly recognized as a valuable biomarker in clinical and genetic studies. However, a direct comparison between cfDNA and gDNA has not been fully explored. In this study, we analyzed cfDNA and gDNA from 186 healthy individuals, using the same sequencing platform. We compared sequencing quality, variant detection, allele frequencies (AF), genotype concordance, population structure, and genomic associati