Area of research
Physiology · Geriatrics and Gerontology
Research interest
Research topics from publications: Insulin-Like Growth Factor Signaling in Alzheimer’s Disease: Pathophysiology and Therapeutic Strategies; Prevalence and correlation of sarcopenia with Alzheimer’s disease: A systematic review and meta-analysis. Representative work: Alzheimer's disease (AD) is the leading cause of dementia among the elderly population, posing a significant public health challenge due to limited therapeutic options that merely delay cognitive decline. AD is associated with impaired energy metabolism and reduced neurotrophic signaling. The insulin-like growth factor (IGF) signaling pathway, crucial for central nervous system (CNS) development, metabolism, repair, cognition, and emotion regulation, includes IGF-1, IGF-2, IGF-1R, IGF-2R, insulin receptor (IR), and six insulin-like growth factor binding proteins (IGFBPs). Research has identified abnormalities in IGF signaling in individuals with AD and AD models. Dysregulated expression of I BACKGROUND: Sarcopenia, which is defined by a decline in skeletal muscle mass and strength associated with aging, is common among older individuals and presents considerable health dangers. Alzheimer's disease (AD) is a prevalent degenerative brain condition linked to a decrease in cognitive function. The intersection of these conditions remains underexplored. The goal of this systematic review and meta-analysis was to establish the frequency of sarcopenia in individuals with AD and investigate the relationship between sarcopenia and AD. METHODS: We performed an extensive review of literature databases, including PubMed, Embase, Web of Science, and the Cochrane Library, through April 2024. T