Area of research
Molecular Biology · Cancer Research
Research interest
Research focused on DNA repair and DNA glycosylase, with related work in Fluoride, Nitrite, Mode of action. Notable publications include 'Toxicity of fluoride: critical evaluation of evidence for human developmental neurotoxicity in epidemiological studies, animal experiments and in vitro analyses', 'Nitrate and nitrite in the diet: How to assess their benefit and risk for human health', and 'Mode of action-based risk assessment of genotoxic carcinogens'.
Commentary of the SKLM to the EFSA opinion on risk assessment of N-nitrosamines in food
Basic concepts of mixture toxicity and relevance for risk evaluation and regulation
Evaluation of the genotoxic potential of acrylamide: Arguments for the derivation of a tolerable daily intake (TDI value)
Salivary nitrate/nitrite and acetaldehyde in humans: potential combination effects in the upper gastrointestinal tract and possible consequences for the in vivo formation of N-nitroso compounds—a hypothesis
Contribution to the ongoing discussion on fluoride toxicity
Toxicity of fluoride: critical evaluation of evidence for human developmental neurotoxicity in epidemiological studies, animal experiments and in vitro analyses
Mode of action-based risk assessment of genotoxic carcinogens
Chromatin recruitment of OGG1 requires cohesin and mediator and is essential for efficient 8-oxoG removal
Environmental aircraft noise aggravates oxidative DNA damage, granulocyte oxidative burst and nitrate resistance in<i>Ogg1</i><sup>–/–</sup>mice
Receptor-mediated Uptake of Folic Acid-functionalized Dextran Nanoparticles for Applications in Photodynamic Therapy
Angiotensin II-induced hypertension increases the mutant frequency in rat kidney
Impaired DNA demethylation of C/EBP sites causes premature aging
DNA Oxidation Photoinduced by Norharmane Rhenium(I) Polypyridyl Complexes: Effect of the Bidentate N,N′‐Ligands on the Damage Profile
DNA damage photo-induced by chloroharmine isomers: hydrolysis<i>versus</i>oxidation of nucleobases
Role of the DNA repair glycosylase OGG1 in the activation of murine splenocytes
Widespread transcriptional gene inactivation initiated by a repair intermediate of 8-oxoguanine
Oxidatively generated base modifications in DNA: Not only carcinogenic risk factor but also regulatory mark?
Albumin–Folate Conjugates for Drug‐targeting in Photodynamic Therapy
Nitroglycerin induces DNA damage and vascular cell death in the setting of nitrate tolerance
Interaction with OGG1 Is Required for Efficient Recruitment of XRCC1 to Base Excision Repair and Maintenance of Genetic Stability after Exposure to Oxidative Stress
Nitrate and nitrite in the diet: How to assess their benefit and risk for human health
Assessment of mechanisms driving non-linear dose–response relationships in genotoxicity testing
hOGG1-Cys326 variant cells are hypersensitive to DNA repair inhibition by nitric oxide
Intra- and extra-cellular DNA damage by harmine and 9-methyl-harmine
Excision of Uracil from Transcribed DNA Negatively Affects Gene Expression
Rapid inactivation and proteasome-mediated degradation of OGG1 contribute to the synergistic effect of hyperthermia on genotoxic treatments
Modulation of base excision repair of 8-oxoguanine by the nucleotide sequence
Mechanisms of DNA damage by photoexcited 9-methyl-β-carbolines
Photogenotoxicity of folic acid
Repair of oxidatively generated DNA damage in Cockayne syndrome