S.P.E.C.I.E.S. · DE
Area of research
Nephrology · Surgery
Research interest
Research interests include Acute Kidney Injury Research, Organ Transplantation Techniques and Outcomes, Renal Transplantation Outcomes and Treatments, and MRI in cancer diagnosis.
Targeting muscle-enriched long non-coding RNA <i>H19</i> reverses pathological cardiac hypertrophy
Genetic Engineering of the Kidney to Permanently Silence MHC Transcripts During ex vivo Organ Perfusion
Interplay of Heme with Macrophages in Homeostasis and Inflammation
Clinical blood sampling for oxylipin analysis – effect of storage and pneumatic tube transport of blood on free and total oxylipin profile in human plasma and serum
Human and murine macrophages exhibit differential metabolic responses to lipopolysaccharide - A divergent role for glycolysis
TLR4 activation alters labile heme levels to regulate BACH1 and heme oxygenase-1 expression in macrophages
Dietary omega-3 PUFA improved tubular function after ischemia induced acute kidney injury in mice but did not attenuate impairment of renal function
Lymphangiogenesis in a mouse model of renal transplant rejection extends life span of the recipients
Labile Heme Aggravates Renal Inflammation and Complement Activation After Ischemia Reperfusion Injury
Formation of trans-epoxy fatty acids correlates with formation of isoprostanes and could serve as biomarker of oxidative stress
Enhanced activation of interleukin-10, heme oxygenase-1, and AKT in C5aR2-deficient mice is associated with protection from ischemia reperfusion injury–induced inflammation and fibrosis
Recent advances in renal imaging
Heme as a Target for Therapeutic Interventions
Integrating MRI and Chemokine Receptor CXCR4-Targeted PET for Detection of Leukocyte Infiltration in Complicated Urinary Tract Infections After Kidney Transplantation
Assessment of acute kidney injury with T1 mapping MRI following solid organ transplantation
Functional MRI for characterization of renal perfusion impairment and edema formation due to acute kidney injury in different mouse strains
Alpha1-antitrypsin binds hemin and prevents oxidative activation of human neutrophils: putative pathophysiological significance
Diffusion‐Weighted imaging and diffusion tensor imaging detect delayed graft function and correlate with allograft fibrosis in patients early after kidney transplantation
Sex matters: Systemic complement activity of female C57BL/6J and BALB/cJ mice is limited by serum terminal pathway components
Multiparametric Functional MRI: Non-Invasive Imaging of Inflammation and Edema Formation after Kidney Transplantation in Mice
Protein kinase C α inhibition prevents peritoneal damage in a mouse model of chronic peritoneal exposure to high-glucose dialysate
Pharmacological targeting of actin-dependent dynamin oligomerization ameliorates chronic kidney disease in diverse animal models
Interleukin 17, Produced by γδ T Cells, Contributes to Hepatic Inflammation in a Mouse Model of Biliary Atresia and Is Increased in Livers of Patients
Oral treatment of rodents with soluble epoxide hydrolase inhibitor 1-(1-propanoylpiperidin-4-yl)-3-[4-(trifluoromethoxy)phenyl]urea (TPPU): Resulting drug levels and modulation of oxylipin pattern
Functional MRI detects perfusion impairment in renal allografts with delayed graft function
Characterization of changes in plasma and tissue oxylipin levels in LPS and CLP induced murine sepsis
A Novel Therapy to Attenuate Acute Kidney Injury and Ischemic Allograft Damage after Allogenic Kidney Transplantation in Mice
Food Polyphenols Fail to Cause a Biologically Relevant Reduction of COX-2 Activity
Extrarenal Progenitor Cells Do Not Contribute to Renal Endothelial Repair