Area of research
Molecular Biology · Cellular and Molecular Neuroscience
Research interest
Research focused on CRISPR and Cas9, with related work in Genome editing, Neurogenesis, Neurodegeneration. Notable publications include 'A Huntingtin Knockin Pig Model Recapitulates Features of Selective Neurodegeneration in Huntington’s Disease', 'Functional disruption of the dystrophin gene in rhesus monkey using CRISPR/Cas9', and 'Promoting Cas9 degradation reduces mosaic mutations in non-human primate embryos'.
Maternal valproic acid exposure leads to neurogenesis defects and autism-like behaviors in non-human primates
CRISPR/Cas9-mediated PINK1 deletion leads to neurodegeneration in rhesus monkeys
A Huntingtin Knockin Pig Model Recapitulates Features of Selective Neurodegeneration in Huntington’s Disease
CRISPR/Cas9-mediated disruption of SHANK3 in monkey leads to drug-treatable autism-like symptoms
Promoting Cas9 degradation reduces mosaic mutations in non-human primate embryos
Altered neurogenesis and disrupted expression of synaptic proteins in prefrontal cortex of SHANK3-deficient non-human primate
CRISPR/Cas9: Implications for Modeling and Therapy of Neurodegenerative Diseases
Functional disruption of the dystrophin gene in rhesus monkey using CRISPR/Cas9
CRISPR/Cas9: a powerful genetic engineering tool for establishing large animal models of neurodegenerative diseases
Mutant Alpha-Synuclein Causes Age-Dependent Neuropathology in Monkey Brain
Aged monkey brains reveal the role of ubiquitin-conjugating enzyme UBE2N in the synaptosomal accumulation of mutant huntingtin